Volatile:ShowField

From Jcbl.jp
Jump to: navigation, search
ID Value
LBF08000BC01 Metabolism=
LBF08000BC02 Metabolism=
LBF08000BC03 Metabolism=
LBF08000HO01 Metabolism=
LBF08000HO02 Metabolism=
LBF08000HO03 Metabolism=
LBF08000HO04 Metabolism=
LBF08000OX01 Metabolism=
LBF08000OX02 Metabolism=
LBF08000OX03 Metabolism=
LBF08000OX04 Metabolism=
LBF08000OX05 Metabolism=
LBF08000OX06 Metabolism=
LBF08000SC01 Metabolism=
LBF08102BC01 Metabolism=
LBF08102BC02 Metabolism=
LBF08102SC01 Metabolism=
LBF08102SC02 Metabolism=
LBF08103BC01 Metabolism=
LBF08103SC01 Metabolism=
LBF08103SC02 Metabolism=
LBF08104SC01 Metabolism=
LBF08105SC01 Metabolism=
LBF08105SC02 Metabolism=
LBF08106BC01 Metabolism=
LBF08106BC02 Metabolism=
LBF08106SC01 Metabolism=
LBF08106SC02 Metabolism=
LBF09000BC01 Metabolism=
LBF09000BC02 Metabolism=
LBF09000BC03 Metabolism=
LBF09000BC04 Metabolism=
LBF09000HO01 Metabolism=
LBF09000HO02 Metabolism=
LBF09000HO03 Metabolism=
LBF09000HO04 Metabolism=
LBF09000HO05 Metabolism=
LBF09000OX01 Metabolism=
LBF09000OX02 Metabolism=
LBF09000OX03 Metabolism=
LBF09000OX04 Metabolism=
LBF09000OX05 Metabolism=
LBF09000SC01 Metabolism=
LBF09101SC01 Metabolism=
LBF09103BC01 Metabolism=
LBF09106SC01 Metabolism=
LBF09107BC01 Metabolism=
LBF09107SC01 Metabolism=
LBF10000BC01 Metabolism=
LBF10000BC02 Metabolism=
LBF10000BC03 Metabolism=
LBF10000BC04 Metabolism=
LBF10000HO01 Metabolism=
LBF10000HO02 Metabolism=
LBF10000HO03 Metabolism=
LBF10000HO04 Metabolism=
LBF10000HO05 Metabolism=
LBF10000OX01 Metabolism=
LBF10000OX02 Metabolism=
LBF10000OX03 Metabolism=
LBF10000OX04 Metabolism=
LBF10000OX05 Metabolism=
LBF10000OX06 Metabolism=
LBF10000OX07 Metabolism=
LBF10000SC01 Metabolism=
LBF10101SC01 Metabolism=
LBF10102SC01 Metabolism=
LBF10105BC01 Metabolism=
LBF10106SC01 Metabolism=
LBF10107SC01 Metabolism=
LBF10108BC01 Metabolism=
LBF10108SC01 Metabolism=
LBF101nnXX01 Metabolism=
LBF10204SC01 Metabolism=
LBF10204SC02 Metabolism=
LBF10204SC03 Metabolism=
LBF10204SC04 Metabolism=
LBF10206SC01 Metabolism=
LBF10206SC02 Metabolism=
LBF10206SC03 Metabolism=
LBF10206SC04 Metabolism=
LBF11000BC01 Metabolism=
LBF11000BC02 Metabolism=
LBF11000BC03 Metabolism=
LBF11000BC04 Metabolism=
LBF11000BC05 Metabolism=
LBF11000BC06 Metabolism=
LBF11000BC07 Metabolism=
LBF11000BC08 Metabolism=
LBF11000BC09 Metabolism=
LBF11000HO01 Metabolism=
LBF11000HO02 Metabolism=
LBF11000OX01 Metabolism=
LBF11000OX02 Metabolism=
LBF11000OX03 Metabolism=
LBF11000OX04 Metabolism=
LBF11000OX05 Metabolism=
LBF11000SC01 Metabolism=
LBF11101SC01 Metabolism=
LBF11102SC01 Metabolism=
LBF11109BC01 Metabolism=
LBF11109BC02 Metabolism=
LBF11109SC01 Metabolism=
LBF12000BC01 Metabolism=
LBF12000BC02 Metabolism=
LBF12000BC03 Metabolism=
LBF12000BC04 Metabolism=
LBF12000BC05 Metabolism=
LBF12000BC06 Metabolism=
LBF12000BC07 Metabolism=
LBF12000BC08 Metabolism=
LBF12000BC09 Metabolism=
LBF12000BC10 Metabolism=
LBF12000BC11 Metabolism=
LBF12000BC12 Metabolism=
LBF12000BC13 Metabolism=
LBF12000BC14 Metabolism=
LBF12000BC15 Metabolism=
LBF12000BC16 Metabolism=
LBF12000BC17 Metabolism=
LBF12000HO01 Metabolism=
LBF12000HO02 Metabolism=
LBF12000HO03 Metabolism=
LBF12000HO04 Metabolism=
LBF12000OX01 Metabolism=
LBF12000OX02 Metabolism=
LBF12000SC01 Metabolism=
LBF12101SC01 Metabolism=
LBF12102PG01 Metabolism=
LBF12102SC01 Metabolism=
LBF12103JA01 Metabolism=
LBF12103SC01 Metabolism=
LBF12105SC01 Metabolism=
LBF12106SC01 Metabolism=
LBF12108SC01 Metabolism=
LBF12110BC01 Metabolism=
LBF12110BC02 Metabolism=
LBF12110CA01 Metabolism=
LBF12110SC01 Metabolism=
LBF121nnCA01 Metabolism=
LBF121nnXX01 Metabolism=
LBF13000BC01 Metabolism=
LBF13000BC02 Metabolism=
LBF13000BC03 Metabolism=
LBF13000BC04 Metabolism=
LBF13000BC05 Metabolism=
LBF13000BC06 Metabolism=
LBF13000BC07 Metabolism=
LBF13000HO01 Metabolism=
LBF13000HO02 Metabolism=
LBF13000HO03 Metabolism=
LBF13000OX01 Metabolism=
LBF13000OX02 Metabolism=
LBF13000OX03 Metabolism=
LBF13000SC01 Metabolism=
LBF13101SC01 Metabolism=
LBF13102SC01 Metabolism=
LBF13111BC01 Metabolism=
LBF13111BC02 Metabolism=
LBF13111SC01 Metabolism=
LBF14000BC01 Metabolism=
LBF14000BC02 Metabolism=
LBF14000BC03 Metabolism=
LBF14000BC04 Metabolism=
LBF14000BC05 Metabolism=
LBF14000BC06 Metabolism=
LBF14000BC07 Metabolism=
LBF14000BC08 Metabolism=
LBF14000BC09 Metabolism=
LBF14000BC10 Metabolism=
LBF14000HO01 Metabolism=
LBF14000HO02 Metabolism=
LBF14000HO03 Metabolism=
LBF14000OX01 Metabolism=
LBF14000OX02 Metabolism=
LBF14000OX03 Metabolism=
LBF14000SC01 Metabolism=
LBF14105SC01 Metabolism=
LBF14106SC01 Metabolism=
LBF14109SC01 Metabolism=
LBF14110SC01 Metabolism=
LBF14112BC01 Metabolism=
LBF14112SC01 Metabolism=
LBF141nnXX01 Metabolism=
LBF15000BC01 Solubility=soluble in acetone , ether , methyl alcohol and petroleum ether.[[Reference:Baer_E:Maurukas_J:,J. Biol. Chem.,1955,212,25
LBF15000BC01 Metabolism=
LBF15000BC02 Metabolism=
LBF15000BC03 Metabolism=
LBF15000BC04 Metabolism=
LBF15000HO01 Metabolism=
LBF15000HO02 Metabolism=
LBF15000HO03 Metabolism=
LBF15000OX01 Metabolism=
LBF15000OX02 Metabolism=
LBF15000OX03 Metabolism=
LBF15000SC01 Metabolism=
LBF15101SC01 Metabolism=
LBF15111BC01 Metabolism=
LBF15113SC01 Metabolism=
LBF15306CV01 Metabolism=Clavirins may possibly be biosynthesized from clavulone.[[Reference:Iwashima_M:Okamoto_K:Iguchi_K:,Tetrahedron Lett.,1999,40,6455
LBF15306CV02 Metabolism=Clavirins may possibly be biosynthesized from clavulone.[[Reference:Iwashima_M:Okamoto_K:Iguchi_K:,Tetrahedron Lett.,1999,40,6455
LBF16000BC01 Solubility=soluble in acetone , ether , methyl alcohol and petroleum ether.[[Reference:Hofmann_K:Lucas_RA:,J. Am. Chem. Soc.,1950,72,4328
LBF16000BC01 Metabolism=
LBF16000BC02 Metabolism=
LBF16000BC03 Metabolism=
LBF16000BC04 Metabolism=
LBF16000BC05 Metabolism=
LBF16000BC06 Metabolism=
LBF16000BC07 Metabolism=
LBF16000BC08 Metabolism=
LBF16000BC09 Metabolism=
LBF16000BC10 Metabolism=
LBF16000BC11 Metabolism=
LBF16000HO01 Metabolism=
LBF16000HO02 Metabolism=
LBF16000HO03 Metabolism=
LBF16000HO04 Metabolism=
LBF16000HO05 Metabolism=
LBF16000HO06 Metabolism=
LBF16000HO07 Metabolism=
LBF16000HO08 Metabolism=
LBF16000HO09 Metabolism=
LBF16000HO10 Metabolism=
LBF16000HO11 Metabolism=
LBF16000OX01 Metabolism=
LBF16000OX02 Metabolism=
LBF16000OX03 Metabolism=
LBF16000OX04 Metabolism=
LBF16000OX05 Metabolism=
LBF16000OX06 Metabolism=
LBF16000OX07 Metabolism=
LBF16000OX08 Metabolism=
LBF16000OX09 Metabolism=
LBF16000PG01 Metabolism=
LBF16000PG02 Metabolism=
LBF16000SC01 Metabolism=
LBF16102PG01 Metabolism=
LBF16106SC01 Metabolism=
LBF16107SC01 Metabolism=
LBF16107SC02 Metabolism=
LBF16109HO01 Metabolism=
LBF16109SC01 Metabolism=
LBF16114BC01 Metabolism=
LBF16114SC01 Metabolism=
LBF161nnXX01 Metabolism=
LBF16204SC01 Metabolism=
LBF16301SC01 Metabolism=
LBF16302SC01 Metabolism=
LBF16303SC01 Metabolism=
LBF16304SC01 Metabolism=
LBF16305SC01 Metabolism=
LBF16306HO01 Metabolism=Metabolism of 12(R)-HETE in corneal tissue produces predominantly the compound resulting from the loss of four carbon atoms through β -oxidation from C-1 [[Reference:Nishimura_M:Schwartzman_ML:Falck_JR:Lumin_S:Zirrolli_JA:Murphy_RC:,Arch. Biochem. Biophys.,1991,290,326
LBF16306SC01 Metabolism=
LBF16401SC01 Metabolism=
LBF16401SC02 Metabolism=
LBF16402SC01 Metabolism=
LBF16403SC01 Metabolism=
LBF17000BC01 Metabolism=
LBF17000BC02 Solubility=soluble in acetone , ether , petroleum ether.[[Reference:Fordyce_CR:Johnson_JR:,J. Am. Chem. Soc.,1933,55,3368
LBF17000BC02 Metabolism=
LBF17000BC03 Metabolism=
LBF17000BC04 Metabolism=
LBF17000HO01 Metabolism=
LBF17000HO02 Metabolism=
LBF17000OX01 Metabolism=
LBF17000SC01 Metabolism=
LBF17101HO01 Metabolism=
LBF17108SC01 Metabolism=
LBF17115BC01 Metabolism=
LBF17115SC01 Metabolism=
LBF17307HO01 Metabolism=12(S)-HHTrE is an excellent substrate for porcine kidney 15-hydroxyprostaglandin dehydrogenase with a K value of 0.8 μ M [[Reference:Liu_Y:Yoden_K:Shen_RF:Tai_HH:,Biochem. Biophys. Res. Commun.,1985,129,268
LBF17307HO02 Metabolism=When prostaglandin H2 reacts with thromboxane A synthase and the endoperoxide moiety is cleaved, the production of thromboxane A2 is accompanied by the formation of 12(S)-hydroxy-5,8,10-heptadecatrienoic acid in an almost equimolar amount liberating malondialdehyde [[Reference:Hamberg_M:Samuelsson_B:,Proc. Natl. Acad. Sci. U. S. A.,1974,71,3400
LBF18000BC01 Metabolism=
LBF18000BC02 Metabolism=
LBF18000BC03 Metabolism=
LBF18000BC04 Metabolism=
LBF18000BC05 Metabolism=
LBF18000BC06 Metabolism=
LBF18000BC07 Metabolism=
LBF18000BC08 Metabolism=
LBF18000BC09 Metabolism=
LBF18000BC10 Metabolism=
LBF18000BC11 Metabolism=
LBF18000HO01 Metabolism=
LBF18000HO02 Metabolism=
LBF18000HO03 Metabolism=
LBF18000HO04 Metabolism=
LBF18000HO05 Metabolism=
LBF18000HO06 Metabolism=
LBF18000HO07 Metabolism=
LBF18000HO08 Metabolism=
LBF18000HO09 Metabolism=
LBF18000HO10 Metabolism=
LBF18000HO11 Metabolism=
LBF18000HO12 Metabolism=
LBF18000HO13 Metabolism=
LBF18000HO14 Metabolism=
LBF18000HO15 Metabolism=
LBF18000HO16 Metabolism=
LBF18000HO17 Metabolism=
LBF18000HO18 Metabolism=
LBF18000HO19 Metabolism=
LBF18000HO20 Metabolism=
LBF18000HO21 Metabolism=
LBF18000HO22 Metabolism=
LBF18000HO23 Metabolism=
LBF18000HO24 Metabolism=
LBF18000HO25 Metabolism=
LBF18000HO26 Metabolism=
LBF18000HO27 Metabolism=
LBF18000HO28 Metabolism=
LBF18000HO29 Metabolism=
LBF18000OX01 Metabolism=
LBF18000OX02 Metabolism=
LBF18000OX03 Metabolism=
LBF18000OX04 Metabolism=
LBF18000OX05 Metabolism=
LBF18000OX06 Metabolism=
LBF18000OX07 Metabolism=
LBF18000SC01 Metabolism=
LBF18000XX01 Metabolism=
LBF18101SC01 Metabolism=
LBF18102HP01 Metabolism=
LBF18102SC01 Metabolism=
LBF18103SC01 Metabolism=
LBF18104HP01 Metabolism=
LBF18104HP02 Metabolism=
LBF18106EO01 Metabolism=
LBF18106EO02 Metabolism=
LBF18106HO01 Metabolism=
LBF18106HO02 Metabolism=
LBF18106HO03 Metabolism=
LBF18106SC01 Metabolism=
LBF18106SC02 Metabolism=
LBF18107EO01 Metabolism=
LBF18107EO02 Metabolism=
LBF18107HO01 Metabolism=
LBF18107HO02 Metabolism=
LBF18107HO03 Metabolism=
LBF18107HO04 Metabolism=
LBF18107HO05 Metabolism=
LBF18107MO01 Metabolism=
LBF18107OX01 Metabolism=
LBF18107OX02 Metabolism=
LBF18107PG01 Metabolism=
LBF18107SC01 Metabolism=
LBF18107SC02 Metabolism=
LBF18108EO01 Metabolism=
LBF18108EO02 Metabolism=
LBF18108HO01 Metabolism=
LBF18108HO02 Metabolism=
LBF18108HO03 Metabolism=
LBF18108HO04 Metabolism=
LBF18108HO05 Metabolism=
LBF18108HO06 Metabolism=
LBF18108HP01 Metabolism=
LBF18108HP02 Metabolism=
LBF18108HP03 Metabolism=
LBF18108HP04 Metabolism=
LBF18108MO01 Metabolism=
LBF18108SC01 Metabolism=
LBF18108SC02 Metabolism=
LBF18109AM01 Metabolism=
LBF18109BC01 Metabolism=
LBF18109EO01 Metabolism=
LBF18109EO02 Metabolism=
LBF18109HO01 Metabolism=
LBF18109HO02 Metabolism=
LBF18109HO04 Metabolism=
LBF18109HO05 Metabolism=
LBF18109HP01 Metabolism=
LBF18109MO01 Metabolism=
LBF18109MO02 Metabolism=
LBF18109MO03 Metabolism=
LBF18109OX01 Metabolism=
LBF18109SC01 Metabolism=In animals oleic acid is synthsized from stearoyl CoA by oxidative desaturation using O2, NADPH, cytochrome b5. Oleic acid is further metabolized to 20:9n-9 via reactions of desaturation and elongation. Essential fatty acid deficincy causes the accumulation of 20:9n-9.
LBF18109SC02 Metabolism=
LBF18110HP01 Metabolism=
LBF18110SC01 Metabolism=
LBF18110SC02 Metabolism=
LBF18111SC01 Metabolism=
LBF18111SC02 Metabolism=
LBF18112SC01 Metabolism=
LBF18112SC02 Metabolism=
LBF18113SC01 Metabolism=
LBF18114SC01 Metabolism=
LBF18115SC01 Metabolism=
LBF18116SC01 Metabolism=
LBF18116SC02 Metabolism=
LBF181nnXX01 Metabolism=
LBF18203EO01 Metabolism=
LBF18203EO02 Metabolism=
LBF18203HO01 Metabolism=
LBF18203HP01 Metabolism=
LBF18203HP02 Metabolism=
LBF18203HP03 Metabolism=
LBF18203HP04 Metabolism=
LBF18203JA02 Metabolism=
LBF18204SC01 Metabolism=
LBF18205HP01 Metabolism=
LBF18205SC01 Metabolism=
LBF18206EO01 Metabolism=
LBF18206HO01 Metabolism=
LBF18206HO02 Metabolism=
LBF18206HO03 Metabolism=
LBF18206HO04 Mass Spectra=GC-EI-MS(after methanolysis and trimethylsilylation)[[Reference:Hamberg_M:,Biochim. Biophys. Acta - Lipids and Lipid Metabolism,1983,752,353
LBF18206HO04 Source=Autooxydation products of linoleic acid in EtOH-water[[Reference:Hamberg_M:,Biochim. Biophys. Acta - Lipids and Lipid Metabolism,1983,752,353
LBF18206HO04 Metabolism=
LBF18206HP01 Metabolism=
LBF18206HP02 Metabolism=
LBF18206HP03 Metabolism=
LBF18206HP04 Metabolism=
LBF18206HP05 Metabolism=
LBF18206OX01 Metabolism=
LBF18206SC01 Metabolism=
LBF18206SC02 Metabolism=
LBF18206SC03 Metabolism=
LBF18206SC04 Metabolism=
LBF18206SC05 Metabolism=Linoleic acid (18:2n-6) is synthesized from oleic acid (18:1n-9) by desaturation of Δ 12-desaturase, and α -linolenic acid (18:3n-3) is formed from linoleic acid by desaturation reaction of Δ 15-desaturase. Since both Δ 12- and 15-desaturases are present in plant cells but not in animal cells, linoleic and α -linolenic acid are not biosynthesized in animal cells in vivo. When ingested by animals, linoleic acid is desaturated, elongated to form γ -linolenic acid (18:3n-6), dihomo- γ -linolenic acid (20:3n-6), arachidonic acid (20:4n-6) and adrenic acid (22:4n-6). Docosapentaenoic acid (22:5n-6) is synthesized from adrenic acid in significant amounts only under conditions of prolonged n-3 fatty acid deficiency., No interconversion between the n-6 and n-3 series in mammals. Nutritionally, it is important to note that different foods contain different proportions of n-6/n-3 and therefore the n-6/n-3 ratio in tissue lipids change significantly depending on the choice of foods.[[Reference:Okuyama_H:Kobayashi_T:Watanabe_S:,Prog. Lipid Res.,1996,35,409
LBF18206SC06 Metabolism=
LBF18206SC07 Metabolism=
LBF18206SC08 Metabolism=
LBF18206SC09 Metabolism=
LBF18206SC10 Metabolism=
LBF18206SC11 Metabolism=
LBF18207HO01 Metabolism=
LBF18207HO02 Metabolism=
LBF18207HO03 Metabolism=
LBF18207HO04 UV Spectra=Methyl ester: λ MeOH/max=230nm(224nm and 238nm)[[Reference:Hamberg_M:,Biochim. Biophys. Acta,1983,752,191
LBF18207HO04 IR Spectra=trans trans unsaturation(990-981cm-1)[[Reference:Hamberg_M:,Biochim. Biophys. Acta,1983,752,191
LBF18207HO04 Source=Reaction products between 13-Hydroperoxylinoleate and human hemoglobin in EtOH[[Reference:Hamberg_M:,Biochim. Biophys. Acta,1983,752,191
LBF18207HO04 Metabolism=
LBF18207HP01 Metabolism=
LBF18207HP02 Metabolism=
LBF18207HP03 Metabolism=
LBF18207MO01 Metabolism=
LBF18207OX01 Metabolism=
LBF18207SC01 Metabolism=
LBF18207SC02 Metabolism=
LBF18207SC03 Metabolism=
LBF18207SC04 Metabolism=
LBF18207TX01 Metabolism=2,3-Dinor-thromboxane B2 is a β -oxidation product of thromboxane B2.
LBF18208HP01 Metabolism=
LBF18208SC01 Metabolism=
LBF18210SC01 Metabolism=
LBF182nnXX02 Metabolism=
LBF18302HP01 Metabolism=
LBF18302HP02 Metabolism=
LBF18302HP03 Metabolism=
LBF18303HP01 Metabolism=
LBF18303HP02 Metabolism=
LBF18303HP03 Metabolism=
LBF18303HP04 Metabolism=
LBF18303HP05 Metabolism=
LBF18303HP06 Metabolism=
LBF18303SC01 Metabolism=Linoleic acid (18:2n-6) is synthesized from oleic acid (18:1n-9) by desaturation of Δ 12-desaturase, and α -linolenic acid (18:3n-3) is formed from linoleic acid by desaturation reaction of Δ 15-desaturase. Since both Δ 12- and 15-desaturases are present in plant cells, α -linolenic acid is synthesized in plants, and relatively enriched in leaves (photosynthetic tissues). On the other hand, these desaturases are not present in animal cells, neither linoleic nor α -linolenic acid is biosynthesized in animal cells in vivo. When ingested by animals, α -linolenic acid is desaturated, elongated and chain-shortened to form eicosapantaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA)[[Reference:Voss_A:Reinhart_M:Sankarappa_S:Sprecher_H:,J. Biol. Chem.,1991,266,19995
LBF18303SC02 Metabolism=
LBF18303SC03 Metabolism=
LBF18304HP01 Metabolism=
LBF18304HP02 Metabolism=
LBF18304HP03 Metabolism=
LBF18304HP04 Metabolism=
LBF18304SC01 Metabolism=
LBF18304SC02 Metabolism=
LBF18304SC03 Metabolism=
LBF18304SC04 Metabolism=
LBF18305SC01 Metabolism=
LBF18305SC02 Metabolism=
LBF18305SC03 Metabolism=
LBF18305SC04 Metabolism=
LBF18305SC05 Metabolism=
LBF18306HO01 Metabolism=
LBF18306HO02 Metabolism=
LBF18306SC01 Metabolism=
LBF18306SC02 Metabolism=Linoleic acid (18:2n-6) is synthesized from oleic acid (18:1n-9) by desaturation of Δ 12-desaturase, and α -linolenic acid (18:3n-3) is formed from linoleic acid by desaturation reaction of Δ 15-desaturase. Since both Δ 12- and 15-desaturases are present in plant cells but not in animal cells, linoleic and α -linolenic acid are not biosynthesized in animal cells in vivo. When ingested by animals, linoleic acid is desaturated, elongated to form γ -linolenic acid (18:3n-6), dihomo- γ -linolenic acid (20:3n-6), arachidonic acid (20:4n-6) and adrenic acid (22:4n-6). Docosapentaenoic acid (22:5n-6) is synthesized from adrenic acid in significant amounts only under conditions of prolonged n-3 fatty acid deficiency., No interconversion between the n-6 and n-3 series in mammals. Nutritionally, it is important to note that different foods contain different proportions of n-6/n-3 and therefore the n-6/n-3 ratio in tissue lipids change significantly depending on the choice of foods.[[Reference:Okuyama_H:Kobayashi_T:Watanabe_S:,Prog. Lipid Res.,1996,35,409
LBF18306SC03 Metabolism=
LBF18306SC04 Metabolism=
LBF18306SC05 Metabolism=
LBF18307HO01 Metabolism=
LBF18307HP01 Metabolism=
LBF18401SC01 Metabolism=
LBF18403SC01 Metabolism=
LBF18403SC02 Metabolism=
LBF18403SC03 Metabolism=
LBF18403SC04 Metabolism=
LBF18403SC05 Metabolism=
LBF19000BC01 Metabolism=
LBF19000BC02 Metabolism=
LBF19000HO01 Metabolism=
LBF19000HO02 Metabolism=
LBF19000SC01 Metabolism=
LBF19109XX01 Metabolism=
LBF19117SC01 Metabolism=
LBF19206HP01 Metabolism=
LBF19206SC01 Metabolism=
LBF20000AM01 Metabolism=
LBF20000AM02 Metabolism=
LBF20000BC01 Metabolism=
LBF20000HO01 Metabolism=
LBF20000HO02 Metabolism=
LBF20000HO03 Metabolism=
LBF20000HO04 Metabolism=
LBF20000PG01 Metabolism=
LBF20000PG02 Metabolism=
LBF20000SC01 Metabolism=
LBF20106SC01 Metabolism=
LBF20107PG01 IR Spectra=METHYL ESTER ; ν 1726, 1717sh, 1699, 980 cm-1 [[Reference:Hayashi_M:Miyamoto_T:,Metabolism and Disease (Taisha),1975,12,1461
LBF20107PG01 NMR Spectra=1H-NMR(CDCl3+DMSO-d6,TMS) : δ 5.70-5.51(m, 2H), 4.14-3.86(m, 2H), 2.72(d,d, 1H)[[Reference:Hayashi_M:Miyamoto_T:,Metabolism and Disease (Taisha),1975,12,1461
LBF20107PG01 Metabolism=Prostagalndin E1 is produced from H1 at almost the same rate of E2 synthesis from H2 by an enzyme of bovine seminal vesicle [[Reference:Ogino_N:Miyamoto_T:Yamamoto_S:Hayaishi_O:,J. Biol. Chem.,1977,252,890
LBF20107PG02 Metabolism=A potential role of 9-hydroxyprostaglandin dehydrogenase was demonstrated in the transformation of prostaglandin I2 to 6-keto-prostaglandin E1 [[Reference:Wong_PY:Lee_WH:Chao_PH:Reiss_RF:McGiff_JC:,J. Biol. Chem.,1980,255,9021
LBF20107PG03 Metabolism=
LBF20107PG04 Metabolism=
LBF20107PG05 Metabolism=
LBF20107PG06 Metabolism=
LBF20107PG07 Metabolism=
LBF20107PG08 Metabolism=
LBF20107PG09 Metabolism=
LBF20107PG10 Metabolism=
LBF20107PG11 Metabolism=
LBF20107PG12 Metabolism=
LBF20107PG13 Metabolism=
LBF20107PG14 Metabolism=
LBF20107PG15 Metabolism=
LBF20107PG17 Metabolism=
LBF20107PG18 Metabolism=6-Keto-prostaglandin F1 α is subjected to β -oxidation, and converted to 2,3-dinor-6-keto-prostaglandin F1 α which appears in urine as a major metabolite [[Reference:Needleman_P:Turk_J:Jakschik_BA:Morrison_AR:Lefkowith_JB:,Annu. Rev. Biochem.,1986,55,69
LBF20107PG19 Metabolism=
LBF20107PG20 Metabolism=
LBF20107PG21 Metabolism=
LBF20107PG22 Metabolism=
LBF20107PG23 Metabolism=
LBF20107PG24 Metabolism=
LBF20107PG25 Metabolism=
LBF20109HO01 Metabolism=
LBF20109SC01 Metabolism=
LBF20109SC02 Metabolism=
LBF20111SC01 Metabolism=
LBF20115PG01 Metabolism=
LBF20115PG02 Metabolism=
LBF20115PG03 Metabolism=
LBF20115PG04 Metabolism=
LBF20115PG05 Metabolism=
LBF20118BC01 Metabolism=
LBF20118BC02 Metabolism=
LBF20203PG01 Metabolism=
LBF20203PG02 Metabolism=
LBF20206HO01 Metabolism=
LBF20206HO02 Metabolism=
LBF20206HP01 Metabolism=
LBF20206SC01 Metabolism=
LBF20207HO01 Metabolism=
LBF20207HO02 Metabolism=
LBF20207HP01 Metabolism=
LBF20207HP02 Metabolism=
LBF20207OX01 Metabolism=
LBF20207PG01 Metabolism=
LBF20207PG02 Metabolism=
LBF20207PG10 Metabolism=
LBF20207PG22 Metabolism=Prostaglandin D2 is produced by isomerization of 9,11-endoperoxide of prostaglandin H2. There are two isozymes of prostaglandin D synthase (hematopoietic type and lipocalin type) distinguished by glutathione reequirement and effect of inhibitor [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257
LBF20207PG23 Metabolism=Prostaglandin E2 is produced from arachidonic acid via prostaglandins G2 and H2 by the catalyses of prostaglandin endoperoxide synthase (cyclooxygenase) [[Reference:Smith_WL:Garavito_RM:DeWitt_DL:,J. Biol. Chem.,1996,271,33157
LBF20207PG24 Metabolism=15-Keto-prostaglandin E2 is further metabolized by its Δ 13-reduction, β -oxidation and ω oxidation. The ultimate metabolite is (7 α -hydroxy-5,11-diketotetranorprosta-1,16-dioic acid) and excreted in urine [[Reference:Hamberg_M:Samuelsson_B:,J. Biol. Chem.,1971,246,6713
LBF20207PG25 Metabolism=Prostaglandin F synthase reduces 9,11-endoperoxide of prostaglandin H2 requiring NADPH, and produces prostaglandin F2 α . The same enzyme also reduces 9-keto group of prostaglandin D2 producing 11 β -prostaglandin F2 [[Reference:Urade_Y:Watanabe_K:Hayaishi_O:,J. Lipid Mediat. Cell Signal.,1995,12,257
LBF20207PG26 Metabolism=15-Keto-prostaglandin F2 α is further metabolized by its Δ 13-reduction, β -oxidation and ω oxidation. The ultimate metabolite is 5 α ,7 α -dihydroxy-11-keto-tetranorprosta-1,16-dioic acid, and excreted in urine [[Reference:Granstrom_E:Samuelsson_B:,J. Biol. Chem.,1971,246,5254
LBF20207PG27 Metabolism=Prostaglandin endoperoxide synthase is a bifunctional enzyme with an oxygenase activity (fatty acid cyclooxygenase) producing prostaglandin G2 from arachidonic acid and a peroxidase activity (prostagladnin hydroperoxidase) converting prostaglandin G2 to prostaglandin H2 . The enzyme is usually referred to briefly as cyclooxygenase. There are two isozymes of the enzyme. Cyclooxygenase-1 is a constitutive enzyme expressed in most mammalian cells, while cyclooxygenase-2 is a product of immediate early gene and is induced rapidly and transiently in certain types of cell by various bioactive compounds [[Reference:Smith_WL:Garavito_RM:DeWitt_DL:,J. Biol. Chem.,1996,271,33157
LBF20207PG28 Metabolism=
LBF20207PG29 Metabolism=
LBF20207PG30 Metabolism=
LBF20207PG31 Metabolism=
LBF20207PG32 Metabolism=
LBF20207PG33 Metabolism=
LBF20207PG34 Metabolism=
LBF20207PG35 Metabolism=
LBF20207PG36 Metabolism=
LBF20207PG37 Metabolism=
LBF20207PG38 Metabolism=
LBF20207PG39 Metabolism=
LBF20207PG40 Metabolism=
LBF20207PG41 Metabolism=
LBF20207PG42 Metabolism=
LBF20207PG43 Metabolism=
LBF20207PG44 Metabolism=
LBF20207PG45 Metabolism=
LBF20207PG46 Metabolism=
LBF20207PG47 Metabolism=
LBF20207PG48 Metabolism=
LBF20207PG49 Metabolism=
LBF20207PG50 Metabolism=
LBF20207PG51 Metabolism=Prostaglandin I2 is produced by isomerization of 9,11-endoperoxide of prostaglandin H2 by the catalysis of prostaglandin I synthase [[Reference:Pace-Asciak_CR:Smith_WL:,The_Enzymes,1983,16,543
LBF20207PG52 Metabolism=
LBF20207PG53 Metabolism=
LBF20207PG54 Metabolism=
LBF20207PG55 Metabolism=
LBF20207PG56 Metabolism=
LBF20207PG57 Metabolism=
LBF20207PG58 Metabolism=
LBF20207PG59 Metabolism=
LBF20207PG60 Metabolism=
LBF20207PG61 Metabolism=
LBF20207PG62 Metabolism=
LBF20207PG63 Metabolism=
LBF20207PG64 Metabolism=
LBF20207PG65 Metabolism=
LBF20207PG66 Metabolism=
LBF20207PG67 Metabolism=
LBF20207PG68 Metabolism=
LBF20207PG69 Metabolism=
LBF20207PG70 Metabolism=
LBF20207PG71 Metabolism=
LBF20207PG72 Metabolism=
LBF20207PG73 Metabolism=
LBF20207PG74 Metabolism=
LBF20207PG75 Metabolism=
LBF20207PG76 Metabolism=
LBF20207PG77 Metabolism=
LBF20207PG78 Metabolism=
LBF20207PG79 Metabolism= 16,16-dimethyl Prostaglandin A1 is a metabolism resistant analogue of PGA1.
LBF20207TX01 Metabolism=Prostaglandin H2 produced by the catalysis of cyclooxygenase is further metabolized to thrombaxne A2 by thromboxane synthaase. Thromboxane A2 is unstable (half life 30 sec) and its oxetane ring is hydrolyzed to hemiacetal thromboxane B2 [[Reference:Needleman_P:Turk_J:Jakschik_BA:Morrison_AR:Lefkowith_JB:,Annu. Rev. Biochem.,1986,55,69
LBF20207TX02 Metabolism=The major urinary metabolite of tromboxane B2 is 2,3-dinor-thromboxane B2 [[Reference:Kindahl_H:,Prostaglandins,1977,13,619
LBF20207TX03 Metabolism=11-Hydroxythromboxane B2 dehydrogenase is considered to be the enzyme responsible for 11-dehydro-thromboxane B2 production [[Reference:Westlund_P:Fylling_AC:Cederlund_E:Jornvall_H:,FEBS Lett.,1994,345,99
LBF20208PG01 Metabolism=
LBF20210PG01 Metabolism=
LBF20212LT01 Metabolism=
LBF20303PG03 Metabolism=
LBF20303PG04 Metabolism=
LBF20303PG05 Metabolism=
LBF20303PG06 Metabolism=
LBF20303PG07 Metabolism=
LBF20303SC01 Metabolism=
LBF20303TX01 Metabolism=Prostaglandin H3 is produced from 5,8,11,14,17-eicosapentaenoic acid, which is one-eighth as efficient a substrate as arachidonic acid, by the catalysis of fatty acid cyclooxygenase, and then transformed to unstable thromboxane A3 [[Reference:Needleman_P:Raz_A:Minkes_MS:Ferrendelli_JA:Sprecher_H:,Proc. Natl. Acad. Sci. U. S. A.,1979,76,944
LBF20303TX02 Metabolism=Prostaglandin H3 is produced from 5,8,11,14,17-eicosapentaenoic acid by the catalysis of fatty acid cyclooxygenase, and then transformed to unstable thromboxane A3 [[Reference:Needleman_P:Raz_A:Minkes_MS:Ferrendelli_JA:Sprecher_H:,Proc. Natl. Acad. Sci. U. S. A.,1979,76,944
LBF20306CV01 Metabolism=Preclavulone lactone may possibly be biosynthesized from preclavulon A. Clavulones may be biosynthesized from preclavulone lactones via clavulolactones by oxygenation at C-12, dehydration between C-7 and C-8, and esterification at C-1 and C-4. [[Reference:Iwashima_M:Watanabe_K:Iguchi_K:,Tetrahedron Lett.,1997,38,8319
LBF20306CV02 Metabolism=Preclavulone lactone may possibly be biosynthesized from preclavulon A. Clavulones may be biosynthesized from preclavulone lactones via clavulolactones by oxygenation at C-12, dehydration between C-7 and C-8, and esterification at C-1 and C-4. [[Reference:Iwashima_M:Watanabe_K:Iguchi_K:,Tetrahedron Lett.,1997,38,8319
LBF20306CV03 Metabolism=
LBF20306EO01 Metabolism=
LBF20306EO02 Metabolism=
LBF20306EO03 Metabolism=
LBF20306HO01 Metabolism=Epoxide hydrolases convert the EpETrEs into vicinal diols[[Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771
LBF20306HO02 Metabolism=
LBF20306HO03 Metabolism=Epoxide hydrolases convert the EpETrEs into vicinal diols[[Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771
LBF20306HO05 Metabolism=
LBF20306HO07 Metabolism=
LBF20306HX01 Metabolism=Trioxilin A3 is produced from hepoxilin A3 by the catalysis of hepoxilin epoxide hydrase of rat liver cytosol [[Reference:Pace-Asciak_CR:Lee_WS:,J. Biol. Chem.,1989,264,9310
LBF20306HX02 Metabolism=Trioxilin B3 is produced by hydrolysis of hepoxilin B3 with ammonium sulfate fraction of rat lung cytosol [[Reference:Pace-Asciak_CR:Reynaud_D:Demin_PM:,Lipids,1995,30,107
LBF20306HX03 Metabolism=The presence of hepoxilin synthase was suggested by a finding that intact cells (skin) and tissue slices (brain hippocampus and pineal gland) transformed 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid to hepoxilins A3 and B3, but tissue boiling inhibited the hepoxilin production [[Reference:Pace-Asciak_CR:Reynaud_D:Demin_PM:,Lipids,1995,30,107
LBF20306HX04 Metabolism=The presence of hepoxilin synthase was suggested by a finding that intact cells (skin) and tissue slices (brain hippocampus and pineal gland) transformed 12(S)-hydroperoxy-5,8,10,14-eicosatetraenoic acid to hepoxilins A3 and B3, but tissue boiling inhibited the hepoxilin production [[Reference:Pace-Asciak_CR:Reynaud_D:Demin_PM:,Lipids,1995,30,107
LBF20306PG01 Metabolism=15-deoxy- Δ 12.14-Prostaglandin D2 is formed from Prostaglandin D2 via Δ 12-Prostaglandin D2. This reaction is proceeded under co-culture with Prostaglandin D2 and serum.[[Reference:Soderstrom_M:Wigren_J:Surapureddi_S:Glass_CK:Hammarstrom_S:,Biochim. Biophys. Acta,2003,1631,35
LBF20306SC01 Metabolism=
LBF20306SC02 Metabolism=
LBF20307HO01 Metabolism=
LBF20307HP01 Metabolism=
LBF20307HP02 Metabolism=
LBF20307PG01 Metabolism=Prostaglandin A2 is produced by non-enzymatic degradation of prostaglandin E2 [[Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552
LBF20307PG02 Metabolism=
LBF20307PG03 Metabolism=Prostaglandin E2 is converted to prostaglandin B2 non-enzymatically at alkaline condition [[Reference:Pike_JE:Lincoln_FH:Schneider_WP:,J. Org. Chem.,1969,34,3552
LBF20307PG04 Metabolism=
LBF20307PG05 Metabolism=Prostaglandin A isomerase converts prostaglandin A2 to C2, and the enzyme is found in human serum [[Reference:Polet_H:Levine_L:,J. Biol. Chem.,1975,250,351
LBF20307PG06 Metabolism=
LBF20307PG38 Metabolism=In aqueous solution prostaglandin D2 undergoes non-enzymatic dehydration and is converted to prostaglandin J2 [[Reference:Fukushima_M:,Prostaglandins Leukot. Essent. Fatty Acids,1992,47,1
LBF20307PG39 Metabolism=
LBF20307PG41 Metabolism=
LBF20308PG01 Metabolism=
LBF20308PG03 Metabolism=In human plasma prostaglandin D2 is dehydrated and converted to 9-deoxy- Δ 9,12-13,14-dihydro-prostaglandin D2 ( Δ 12-prostaglandin J2) catalyzedby serum albumin [[Reference:Narumiya_S:Fukushima_M:,Biochem. Biophys. Res. Commun.,1985,127,739
LBF20309EO01 Metabolism=Dramatic increases in urinary (±)14,15-DiHETrE, a (±)14(15)-EpETrE metabolite, have been documented by GC/MS in pregnancy induced hypertension [[Reference:Catella_F:Lawson_JA:Fitzgerald_DJ:FitzGerald_GA:,Proc. Natl. Acad. Sci. U. S. A.,1990,87,5893
LBF20309HO01 Metabolism=Epoxide hydrolases convert the EpETrEs into vicinal diols[[Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771
LBF20309HO02 Metabolism=
LBF20309SC01 Metabolism=
LBF20402SC01 Metabolism=
LBF20403PG03 Metabolism=
LBF20403PG04 Metabolism=
LBF20403SC01 Metabolism=
LBF20404SC01 Metabolism=
LBF20406AM01 Metabolism=
LBF20406AM02 Metabolism=
LBF20406AM03 Metabolism=
LBF20406AM04 Metabolism=
LBF20406AM05 Metabolism=
LBF20406AM06 Metabolism=
LBF20406AM07 Metabolism=
LBF20406AM08 Metabolism=
LBF20406AM09 Metabolism=
LBF20406AM10 Metabolism=
LBF20406AM11 Metabolism=
LBF20406AM12 Metabolism=
LBF20406AM13 Metabolism=
LBF20406AM14 Metabolism=
LBF20406AM15 Metabolism=
LBF20406AM16 Metabolism=
LBF20406AM17 Metabolism=
LBF20406AM18 Metabolism=
LBF20406AM19 Metabolism=
LBF20406AM20 Metabolism=
LBF20406AM21 Metabolism=
LBF20406AM22 Metabolism=
LBF20406AM23 Metabolism=
LBF20406AM24 Metabolism=
LBF20406AM25 Metabolism=
LBF20406AM26 Metabolism=
LBF20406AM27 Metabolism=
LBF20406AM28 Metabolism=
LBF20406AM29 Metabolism=
LBF20406AM30 Metabolism=
LBF20406AM31 Metabolism=
LBF20406AM32 Metabolism=
LBF20406AM33 Metabolism=
LBF20406AM34 Metabolism=
LBF20406AM35 Metabolism=
LBF20406AM36 Metabolism=
LBF20406AM37 Metabolism=
LBF20406AM38 Metabolism=
LBF20406AM39 Metabolism=
LBF20406AM40 Metabolism=
LBF20406AM41 Metabolism=
LBF20406AM42 Metabolism=
LBF20406AM43 Metabolism=
LBF20406AM44 Metabolism=
LBF20406AM45 Metabolism=
LBF20406AM46 Metabolism=
LBF20406CV01 Metabolism=
LBF20406CV02 Metabolism=
LBF20406CV03 Metabolism=
LBF20406CV04 Metabolism=
LBF20406CV05 Metabolism=The biosynthesis of clavulone is suggested to proceed from arachidonic acid via 8(R)-HEPETE and pre-clavulone A.[[Reference:Corey_EJ:,Experientia,1983,39,1084
LBF20406CV06 Metabolism=The biosynthesis of clavulones is suggested to proceed from arachidonic acid via 8(R)-HEPETE and pre-clavulone A.[[Reference:Corey_EJ:,Experientia,1983,39,1084
LBF20406CV07 Metabolism=The biosynthesis of clavulones is suggested to proceed from arachidonic acid via 8(R)-HEPETE and pre-clavulone A.[[Reference:Corey_EJ:,Experientia,1983,39,1084
LBF20406CV08 Metabolism=The biosynthesis of clavulones is suggested to proceed from arachidonic acid via 8(R)-HEPETE and pre-clavulone A.[[Reference:Corey_EJ:,Experientia,1983,39,1084
LBF20406CV09 Metabolism=
LBF20406CV10 Metabolism=
LBF20406CV11 Metabolism=
LBF20406CV12 Metabolism=
LBF20406CV13 Metabolism=
LBF20406CV14 Metabolism=
LBF20406CV15 Metabolism=
LBF20406CV16 Metabolism=
LBF20406CV17 Metabolism=
LBF20406CV18 Metabolism=
LBF20406EO01 Metabolism=
LBF20406HO07 Metabolism=Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA to 5,6-DiHETE[[Reference:Haeggstrom_J:Wetterholm_A:Hamberg_M:Meijer_J:Zipkin_R:Radmark_O:,Biochim. Biophys. Acta,1988,958,469
LBF20406HO08 Metabolism=
LBF20406HO09 Metabolism=
LBF20406HO10 Metabolism=
LBF20406HO11 Metabolism=5(S)-HETE is metabolized to 5-OxoETE by a 5-hydroxyeicosanoid dehydrogenase present in intact human polymorphonuclear leukocytes [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233
LBF20406HO12 Metabolism=The precursor of 8(R)-HETE, 8(R)-HpETE, is the putative intermediate in the biosynthesis of marine prostaglandins via the allene oxide synthase pathway.[[Reference:Brash_AR:Baertschi_SW:Ingram_CD:Harris_TM:,J. Biol. Chem.,1987,262,15829
LBF20406HO13 Metabolism=8(S)-HETE is synthesized from arachidonic acid by a 8(S)-lipoxygenase present in phorbol ester-treated mouse skin [[Reference:Hughes_MA:Brash_AR:,Biochim. Biophys. Acta,1991,1081,347
LBF20406HO14 Metabolism=
LBF20406HO15 Metabolism=
LBF20406HO16 Metabolism=
LBF20406HO17 Metabolism=
LBF20406HO18 Metabolism=12(R)-HETE is the predominant stereoisomer produced by psoriatic skin scales and rat liver microsomal cytochrome P-450 [[Reference:Woollard_PM:,Biochem. Biophys. Res. Commun.,1986,136,169
LBF20406HO19 Metabolism=20-HETE is a cytochrome P metabolite of arachidonic acid [[Reference:Hatzelmann_A:Ullrich_V:,Eur. J. Biochem.,1988,173,445
LBF20406HO20 Metabolism=When arachidonic acid is oxygenated by 5-lipoxygenase, 5(S)-hydroperoxy-6,,8,11,14-(E,Z,Z,Z)-eicosatetraenoic acid is produced [[Reference:Ford-Hutchinson_AW:Gresser_M:Young_RN:,Annu. Rev. Biochem.,1994,63,383
LBF20406HO21 Metabolism=When arachidonic acid is oxygenated by 12-lipoxygenase, 12(S)-hydroperoxy-5,8,10,14-(Z,Z,E,Z)-eicosatetraenoic acid is produced [[Reference:Yamamoto_S:Suzuki_H:Ueda_N:,Prog. Lipid Res.,1997,36,23
LBF20406HO22 Metabolism=
LBF20406HO23 Metabolism=12(S)-HETE is a metabolite of arachidonic acid via the 12-lipoxygenase pathway [[Reference:Hamberg_M:Samuelsson_B:,Proc. Natl. Acad. Sci. U. S. A.,1974,71,3400
LBF20406HP01 Metabolism=
LBF20406HP02 Metabolism=
LBF20406HP03 Metabolism=
LBF20406HP04 Metabolism=
LBF20406HP05 Metabolism=
LBF20406HP06 Metabolism=
LBF20406HP07 Metabolism=
LBF20406HP08 Metabolism=
LBF20406HP09 Metabolism=
LBF20406HP10 Metabolism=
LBF20406LT01 Metabolism=Arachidonate 5-lipoxygenase is a bifunctional enzyme with a 5-oxygenase activity converting arachidonic acid to 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid and a leukotriene A synthase activity converting the 5-hydroperoxy acid to leukotriene A4. The same enzyme produces leukotriene A4 from arachidonic acid via 5-hydroperoxy acid [[Reference:Ford-Hutchinson_AW:Gresser_M:Young_RN:,Annu. Rev. Biochem.,1994,63,383
LBF20406LT02 Metabolism=Arachidonic acid is metabolized to leukotrienen A4 with 5,6-epoxide by 5-lipoxygenases, and the product is further transformed to leukotrienee B4 by leukotriene A hydrolase [[Reference:Ford-Hutchinson_AW:Gresser_M:Young_RN:,Annu. Rev. Biochem.,1994,63,383
LBF20406LT03 Metabolism=
LBF20406LT04 Metabolism=
LBF20406LT05 Metabolism=
LBF20406LT06 Metabolism=
LBF20406LT07 Metabolism=
LBF20406LT08 Metabolism=
LBF20406LT09 Metabolism=
LBF20406LT10 Metabolism=
LBF20406LT11 Metabolism=
LBF20406LT12 Metabolism=
LBF20406LT13 Metabolism= γ -Glutamyl transpeptidase hydrolyzes the glutathione moiety of leukotriene C4 and produces leukotriene D4 liberating glutamic acid [[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355
LBF20406LT14 Metabolism=Arachidonic acid is metabolized to leukotrienen A4 with 5,6-epoxide by 5-lipoxygenases, and the product is further transformed to leukotrienee C4 incorporating glutathione by the catalysis of leukotriene C synthase [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1
LBF20406LT15 Metabolism=
LBF20406LT16 Metabolism=
LBF20406LT17 Metabolism=Leukotriene D4 is converted to E4 by extracellular action of a dipeptidase released from granules of human polymorphonuclear leukocytes [[Reference:Lee_CW:Lewis_RA:Corey_EJ:Austen_KF:,Immunology,1983,48,27
LBF20406LT18 Metabolism=
LBF20406LT19 Metabolism=Upon subcutaneous injection of leukotriene C4 in rats N-acetyl leukotriene E4 and N-acetyl 11-trans-leukotriene E4 are found in feces. Leukotriene E4 is transformed to N-acetyl leukotriene E4 by incubation with rat liver microsomes [[Reference:Hammarstrom_S:Orning_L:Bernstrom_K:,Mol. Cell. Biochem.,1985,69,7
LBF20406LT20 Metabolism=Leukotriene E4 is transformed to leukotriene F4 by γ -glultamyltransferase in the presence of glutathione [[Reference:Hammarstrom_S:Orning_L:Bernstrom_K:,Mol. Cell. Biochem.,1985,69,7
LBF20406OX01 Metabolism=
LBF20406OX02 Metabolism=
LBF20406PG02 Metabolism=
LBF20406PH01 Metabolism=
LBF20406SC01 Metabolism=Metabolic product of linoleic acid (9,12-18:2). The synthesis of 5,8,11,14-20:4 occurs via the following reaction sequence in the endoplasmic reticulum [[Reference:Sprecher_H:Luthria_DL:Mohammed_BS:Baykousheva_SP:,J. Lipid. Res.,1995,36,2471
LBF20407HO02 Metabolism=
LBF20407HO04 Metabolism=
LBF20407HO05 Metabolism=(±)15-HETE, an autoxidation product of arachidonic acid, is comprised of an equal mixture of 15(R)- and 15(S)-HETE. Aspirin-inactivated human recombinant and ovine COX-2 metabolizes arachidonic acid to 15(R)-HETE [[Reference:Lecomte_M:Laneuville_O:Ji_C:DeWitt_DL:Smith_WL:,J. Biol. Chem.,1994,269,13207
LBF20407HO06 Metabolism=
LBF20407HO07 Metabolism=When arachidonic acid is oxygenated by 15-lipoxygenase, 15(S)-hydroperoxy-5,8,11,13-(Z,Z,Z,E)-eicosatetraenoic acid is produced [[Reference:Bryant_RW:Bailey_JM:Schewe_T:Rapoport_SM:,J. Biol. Chem.,1982,257,6050
LBF20407HP01 Metabolism=
LBF20407LX01 Metabolism=Dual lipoxygenation pathways are considered for lipoxin A4 synthesis from arachidonic acid; either 15-lipoxygenase and 5-lipoxygenase in leukocytes or 5-lipoxygenase in leukocytes and 12-lipoxygenase in platelets [[Reference:Serhan_CN:,Biochim._Biophys._Acta,1994,1212,1
LBF20407OX01 Metabolism=
LBF20408LX01 Metabolism=
LBF20502SC01 Metabolism=
LBF20503HO01 Metabolism=
LBF20503HO02 Metabolism=
LBF20503HO03 Metabolism=
LBF20503HO04 Metabolism=
LBF20503HO05 Metabolism=
LBF20503HO06 Metabolism=
LBF20503HO07 Metabolism=
LBF20503HO08 Metabolism=
LBF20503HO09 Metabolism=
LBF20503HP01 Metabolism=
LBF20503HP02 Metabolism=
LBF20503HP03 Metabolism=
LBF20503HP04 Metabolism=
LBF20503HP05 Metabolism=
LBF20503HP06 Metabolism=
LBF20503HP07 Metabolism=
LBF20503HP08 Metabolism=
LBF20503LT01 Metabolism=Leukotriene B5 is produced via leukotriene A5 from 5,8,11,14,17-eicosapentaenoic acid, which is almost as active as arachidonic acid as substrate [[Reference:Yamamoto_S:,Biochim. Biophys. Acta,1992,1128,117
LBF20503SC01 Metabolism=Metabolic product of α -linolenic acid (9,12,15-18:3). The synthesis of 5,8,11,14,17-20:5 (=EPA) occurs via the following reaction sequence in the endoplasmic reticulum [[Reference:Sprecher_H:Luthria_DL:Mohammed_BS:Baykousheva_SP:,J. Lipid. Res.,1995,36,2471
LBF21000BC01 Metabolism=
LBF21000HO01 Metabolism=
LBF21000SC01 Metabolism=
LBF21503HO04 Metabolism=
LBF22000BC01 Metabolism=
LBF22000HO01 Metabolism=
LBF22000HO02 Metabolism=
LBF22000HO03 Metabolism=
LBF22000SC01 Metabolism=
LBF22107PG02 Metabolism=
LBF22109SC01 Metabolism=
LBF22109SC02 Metabolism=
LBF22111SC01 Metabolism=
LBF22206SC01 Metabolism=
LBF22209PG13 Metabolism=
LBF22209SC01 Metabolism=
LBF222nnPG01 Metabolism=
LBF22308SC01 Metabolism=
LBF22309SC01 Metabolism=
LBF22403SC01 Metabolism=
LBF22406SC01 Metabolism=
LBF22408AM01 Metabolism=
LBF22408AM02 Metabolism=
LBF22408AM03 Metabolism=
LBF22408AM04 Metabolism=
LBF22408AM05 Metabolism=
LBF22409SC01 Metabolism=
LBF22503SC01 Metabolism=
LBF22503SC02 Metabolism=
LBF22506SC01 Metabolism=The synthesis of 4,7,10,13,16-22:5 occurs via the following reaction sequence [[Reference:Sprecher_H:Luthria_DL:Mohammed_BS:Baykousheva_SP:,J. Lipid. Res.,1995,36,2471
LBF22603SC01 Metabolism=Metabolic product of α -linolenic acid (9,12,25-18:3). The synthesis of 4,7,10,13,16,19-22:6 (=DHA) occurs via the following reaction sequence [[Reference:Sprecher_H:Luthria_DL:Mohammed_BS:Baykousheva_SP:,J. Lipid. Res.,1995,36,2471
LBF23000BC01 Metabolism=
LBF23000BC02 Metabolism=
LBF23000SC01 Metabolism=
LBF23101SC01 Metabolism=
LBF232nnPG01 Metabolism=
LBF232nnPG02 Metabolism=
LBF232nnPG03 Metabolism=
LBF232nnPG04 Metabolism=
LBF24000BC01 Metabolism=
LBF24000HO01 Metabolism=
LBF24000SC01 Metabolism=
LBF24109HO01 Metabolism=
LBF24109SC01 Metabolism=
LBF24109SC02 Metabolism=
LBF24122BC01 Metabolism=
LBF24603SC01 Metabolism=
LBF25000BC01 Metabolism=
LBF25000SC01 Metabolism=
LBF26000BC01 Metabolism=
LBF26000SC01 Metabolism=
LBF26109SC01 Metabolism=
LBF26117SC01 Metabolism=
LBF26206SC01 Metabolism=
LBF27000BC01 Metabolism=
LBF27000SC01 Metabolism=
LBF28000BC01 Metabolism=
LBF28000SC01 Metabolism=
LBF28109SC01 Metabolism=
LBF29000SC01 Metabolism=
LBF30000BC01 Metabolism=
LBF30000SC01 Metabolism=
LBF30109SC01 Metabolism=
LBF31000SC01 Metabolism=
LBF32000SC01 Metabolism=
LBF32109SC01 Metabolism=
LBF33000SC01 Metabolism=
LBF34000SC01 Metabolism=
LBF35000SC01 Metabolism=
LBF36000SC01 Metabolism=
LBF37000SC01 Metabolism=
LBF38000SC01 Metabolism=
LBF46000SC01 Metabolism=


Personal tools