Volatile:ShowField

From Jcbl.jp
Jump to: navigation, search
ID Value
LBF12103JA01 Biological Activity=At concentrations above 10 -6 M, cucurbic acid exhibits strong tuber-inducing activity in single-node segments of etiolated potato shoots[[Reference:Koda_Y:Kikuta_Y:Tazaki_H:Tsujino_Y:Sakamura_S:Yoshihara_T:,Phytochemistry.,1991,30,1435
LBF12110CA01 Biological Activity=Traumatic acid is a wound-healing agent that stimulates cell division near a wound site to form a protective callus .
LBF121nnCA01 Biological Activity=Traumatic acid is a wound-healing agent that stimulates cell division near a wound site to form a protective callus .
LBF15306CV01 Biological Activity=Clavirins showed growth-inhibitory activity toward Hela S3 at 1 μ g/ml.[[Reference:Iwashima_M:Okamoto_K:Iguchi_K:,Tetrahedron Lett.,1999,40,6455
LBF15306CV02 Biological Activity=Clavirins showed growth-inhibitory activity toward Hela S3 at 1 μ g/ml.[[Reference:Iwashima_M:Okamoto_K:Iguchi_K:,Tetrahedron Lett.,1999,40,6455
LBF17101HO01 Biological Activity=12S-Hydroxy-16-heptadecynoic acid inhibits prostaglandin &ω; -hydroxylase with a Kiof 1.8 &μ; M [[Reference:Burger_A:Clark_JE:Nishimoto_M:Muerhoff_AS:Masters_BS:Ortiz_de_Montellano_PR:,J. Med. Chem.,1993,36,1418
LBF17307HO01 Biological Activity=At a concentration of 0.5 &μ; M 12(S)-HHTrE stimulates prostacyclin production in human endothelial cells [[Reference:Sadowitz_PD:Setty_BN:Stuart_M:,Prostaglandins,1987,34,749
LBF17307HO02 Biological Activity=The compound stimulates chemotactic and chemokinetic activities of human polymorphonuclear leukocytes [[Reference:Goetzl_EJ:Gorman_RR:,J. Immunol.,1978,120,526
LBF18000BC10 Biological Activity=[[Reference:Freeman_NK:,J. Am. Chem. Soc.,1952,74,2523
LBF18000BC11 Biological Activity=[[Reference:Freeman_NK:,J. Am. Chem. Soc.,1952,74,2523
LBF18102HP01 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18104HP02 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18106EO01 Biological Activity=Antimicrobial compounds for Piricularia oryzae, a pathogenic fungus of rice blast disease (Imochi-byo)[[Reference:Kato_T:Yamaguthi_H:Uehara_T:Namai_T:,Chemistry and Biology (in Japanese),1986,24,183
LBF18107HO04 Biological Activity=It showed a toxicity corresponding to linoleate monohydroxyperoxide[[Reference:Fujimoto_K:,Fragrance J. (in Japanese),1986,76,21
LBF18108HO04 Biological Activity=It showed a toxicity corresponding to linoleate monohydroxyperoxide[[Reference:Fujimoto_K:,Fragrance J. (in Japanese),1986,76,21
LBF18108HP01 Biological Activity=It showed a slightly higher toxicity than linoleate monohydroxyperoxide.[[Reference:Fujimoto_K:,Fragrance J. (in Japanese),1986,76,21
LBF18108HP04 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18109AM01 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CBl)was not found. [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF18109EO01 Biological Activity=Antimicrobial compounds for Piricularia oryzae, a pathogenic fungus of rice blast disease (Imochi-byo)[[Reference:Kato_T:Yamaguthi_H:Uehara_T:Namai_T:,Chemistry and Biology (in Japanese),1986,24,183
LBF18110HP01 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18203HP01 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18203HP02 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18203HP03 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18203JA02 Biological Activity=12-oxo PDA is the precursor of the biologically active 7-epi jasmonic acid which is a plant growth inhibitor and senescence inducer [[Reference:Hamberg_M:Gardner_HW:,Biochim. Biophys. Acta,1992,1165,1
LBF18206HO03 Biological Activity=Trans, trans isomer showed a slightly lower toxicity than linoleate monohydroxyperoxide[[Reference:Fujimoto_K:,Fragrance J. (in Japanese),1986,76,21
LBF18206HP01 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18206HP02 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18206HP03 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18206OX01 Biological Activity=It showed a slightly lower toxicity than linoleate monohydroxyperoxide[[Reference:Fujimoto_K:,Fragrance J. (in Japanese),1986,76,21
LBF18206SC05 Biological Activity=There are two groups of essential fatty acids for mammals, the n-6 (or ω 6) and the n-3 (or ω 3). Linoleic acid (LA) is one of the n-6 essential fatty. Animals deficient in LA show the growth retardation, skin lesions, reproductive failure, fatty liver and polydipsia [[Reference:Paulsrud_JR:Pensler_L:Whitten_CF:Stewart_S:Holman:RT:,Am. J. Clin. Nutr.,1972,25,897
LBF18207HO03 Biological Activity=Trans, trans configuration showed a slightly lower toxicity than linoleate monohydroxyperoxide[[Reference:Fujimoto_K:,Fragrance J. (in Japanese),1986,76,21
LBF18207HP01 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18207HP03 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18207OX01 Biological Activity=It showed a slightly lower toxicity than linoleate monohydroxyperoxide[[Reference:Fujimoto_K:,Fragrance J. (in Japanese),1986,76,21
LBF18302HP01 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18302HP02 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18302HP03 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18303HP01 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18303HP02 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18303HP03 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18303HP04 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18303HP05 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18303HP06 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18303SC01 Biological Activity=Dietary α -linolenic acid can be further elongated and desaturated to form the long-chain n-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosapentaenoic acid (DHA), which are uniquely rich in neural membranes of retina and brain in mammals. It has been reported that n-3 fatty acid deficiency produces reduced learning ability[[Reference:Yamamoto_N:Saitoh_M:Moriuchi_A:Nomura_M:Okuyama_H:,J. Lipid. Res.,1987,28,144
LBF18304HP01 Biological Activity=Pysiological damages are induced by these hydroperoxides which are incorporated into bodies or synthesized endogenously.[[Reference:Logani_MK:Davies_RE:,Lipids,1980,15,485
LBF18304HP02 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18304HP03 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18304HP04 Biological Activity=It reacts with DNA in the presence of Fe ions and ascorbic acid[[Reference:Fujimoto_K:Neff_WE:Frankel_EN:,Biochim. Biophys. Acta,1984,795,100
LBF18306SC02 Biological Activity=There are two groups of essential fatty acids, the n-6 (or ω 6) and the n-3 (or ω 3). γ -linolenic acid is n-6 fatty acids. Essential fatty acid deficiency causes skin lesion and growth retardation. Dietary supplementation of either linoleate, γ -linoleate or arachidonate prevents such symptoms completely. The n-6 essential fatty acids have at least four roles [[Reference:Horrobin_DF:,Prog. Lipid Res.,1992,31,163
LBF20000AM01 Biological Activity=[[:Template:Image200
LBF20000AM02 Biological Activity=[[:Template:Image200
LBF20000PG01 Biological Activity=13,14-dihydro PGE1 is an inhibitor of ADP-induced platelet aggregation in human PRP.
LBF20000PG02 Biological Activity=13,14-dihydro-15keto PGE1 is a week inhibitor of ADP-induced platelet aggregation in human PRP.
LBF20107PG01 Biological Activity=Prostaglandin E1 is generally considered as active as E2, and the biological activities of both compounds are compared in references [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1
LBF20107PG02 Biological Activity=6-Keto-prostaglandin E1 is a stable metabolite. The compound inhibits platelet aggregation with activity comparable or greater than prostaglandin D2 although less potent than prostaglandin I2. Its vasodilatory and hypotensive activities, bronchodilatory property, and inhibition of gastric acid secretion were reported [[Reference:Moore_PK:Griffiths_RJ:,Prostaglandins,1983,26,509
LBF20107PG03 Biological Activity=In terms of contraction of gastrointestinal smooth muscles, prostaglandin F1 α was repoprted to be about 10 times less active than prostaglandin F2 α [[Reference:Horton_EW:,Physiol. Rev.,1969,49,122
LBF20107PG04 Biological Activity=15-keto PGE1 has very slight biological activity compared to PGE1.[[Reference:Westwick_J:,Br. J. Pharmacol.,1976,58,297P
LBF20107PG05 Biological Activity= 19(R)-hydroxy PGE1 has contractile activity on smooth muscle preparations.[[Reference:Kelly_RW:Taylor_PL:Hearn_JP:Short_RV:Martin_DE:Marston_JH:,Nature,1976,260,544
LBF20107PG06 Biological Activity=In fish, the 15-keto compounds (including 15-keto PGF1 α ) serve as post-ovulatory pheromones and are more active tha the parent prostaglandins.[[Reference:Sorensen_PW:Hara_TJ:Stacey_NE:Goetz_FW:,Biol Reprod.,1988,39,1039
LBF20107PG08 Biological Activity=Prostaglandin D1 inhibits ADP-induced human platelet aggregation effect (IC50 value of 320 ng/ml). [[Reference:Bundy_GL:Morton_DR:Peterson_DC:Nishizawa_EE:Miller_WL:,J. Med. Chem.,1983,26,790
LBF20107PG09 Biological Activity=Prostaglandin E1 Alcohol shows bronchodialational effect on human respiratory tract muscle.[[Reference:Nizankowska_E:Sheridan_AQ:Maile_MH:Cross_CJ:Nizankowski_R:Prochowska_K:Szczeklik_A:,Prostaglandins,1985,29,349
LBF20107PG10 Biological Activity= 11-deoxy Prostaglandin E1 shows spieces and subtype dependent EP agonistic effect. In guinea pig, 11-deoxy Prostaglandin E1 induce bronchodilation and vasodepression. [[Reference:Hall_DW:Jaitly_KD:,Prostaglandins,1976,11,573
LBF20107PG11 Biological Activity=15(R)-Prostaglandin E1 dosen't have biological significance but inhibit 15-hydroxy PGDH (IC50 value of 189 μ M).[[Reference:Jarabak_J:Braithwaite_SS:,Arch. Biochem. Biophys.,1976,177,245
LBF20107PG12 Biological Activity=11-deoxy Prostaglandin F1 α shows inhibits gastric acid secretion and induces uterine constriction. [[Reference:Lippmann_W:,J. Pharm. Pharmacol.,1969,21,335
LBF20107PG13 Biological Activity=Prostaglandin F1 β increase respiratory rate after application intravenously.[[Reference:Brookes_LG:Marshall_RC:,J. Pharm. Pharmacol.,1974,26 Suppl,80
LBF20107PG14 Biological Activity=11-deoxy Prostaglandin F1 β shows vasodepression and bronchodilationeffect in guinea pig.[[Reference:Hall_DW:Jaitly_KD:,Prostaglandins,1976,11,573
LBF20107PG15 Biological Activity=11 β -PGE1 is reported to contract the rat uterus and guinea pig ileum with less potent activity.[[Reference:Ramwell_PW:Shaw_JE:Corey_EJ:Andersen_N:,Nature,1969,221,1251
LBF20107PG17 Biological Activity=11-deoxy PGF1 β shows vasodepressor and bronchodilator activities in guinea pigs at a dose of 500 μ g/kg.[[Reference:Hall_DW:Jaitly_KD:,Prostaglandins,1976,11,573
LBF20107PG18 Biological Activity=Degradation of prostaglandin I2 to 6-keto-prostaglandin F1 α brings about the loss of biological activities. For example, the hypotensive effect of prostaglandin I2 is at least 100 times mor active than 6-keto-prostaglandin F1 α [[Reference:Moncada_S:Vane_JR:,Pharmacol. Rev.,1978,30,293
LBF20107PG19 Biological Activity=8-iso PGE1 is reported as a pulmonary vasoconstrictor in anesthetized dogs at similar concentration to PGF2 α .[[Reference:Nakano_J:Kessinger_JM:,Proc. Soc. Exp. Biol. Med.,1970,133,1314
LBF20107PG20 Biological Activity=6 α -PGI1 is reported to promote cAMP accumulation in human thyroied slices and cells in a concentration dependent manner.[[Reference:Leighton_JK:DeBrunner-Vossbrinck_BA:Kemper_B:,Biochemistry,1984,23,204
LBF20107PG21 Biological Activity=6 β -PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μ M compared with 18 nM for PGI2.[[Reference:Whittle_BJ:Moncada_S:Whiting_F:Vane_JR:,Prostaglandins,1980,19,605
LBF20107PG22 Biological Activity=15(S)-15-methyl Prostaglandin E1 shows weak constriction effect on human respiratory tract smooth muscle.[[Reference:Karim_SM:Adaikan_PG:Kottegoda_SR:,Adv. Prostaglandin Thromboxane Leukot. Res.,1980,7,969
LBF20107PG23 Biological Activity=PGH1 is known as suicide substrate and inhibits platelet thromboxane synthase with a Ki of 28 μ M.[[Reference:Jones_DA:Fitzpatrick_FA:,J. Biol. Chem.,1990,265,20166
LBF20107PG24 Biological Activity= 16,16-dimethyl Prostaglandin E1 shows vascular constriction in human.[[Reference:Karim_SM:Adaikan_PG:Kottegoda_SR:,Adv. Prostaglandin Thromboxane Leukot. Res.,1980,7,969
LBF20107PG25 Biological Activity=6,15-diketo-13,14-dihydro PGF1 α is hown to enhance the intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells.[[Reference:Etingin_OR:Weksler_BB:Hajjar_DP:,J. Lipid Res.,1986,27,530
LBF20115PG04 Biological Activity= 13,14-dihydro Prostaglandin F2 α induce leuteolysis in hamster.[[Reference:Andersen_NH:Imamoto_S:Subramanian_N:Picker_DH:Ladner_DW:De_B:Tynan_SS:Eggerman_TL:Harker_LA:Robertson_RP_et_al:,Prostaglandins,1981,22,841
LBF20115PG05 Biological Activity=8-iso-13,14-dihydro-15-keto PGF2 α weakly has been reported to inhibit the U-46619 or collagen-induced platelet aggregation.[[Reference:Cranshaw_JH:Evans_TW:Mitchell_JA:,Br. J. Pharmacol.,2001,132,1699
LBF20203PG01 Biological Activity= Δ 17-PGE1 is about half as potent as PGE1 as an inhibitor of ADP-induced aggregation of rabbbit PRP.[[Reference:Kobzar_G:Mardla_V:Jarving_I:Lohmus_M:Vahemets_A:Samel_N:Lille_U:,Comp. Biochem. Physiol. C,1993,106,489
LBF20207HO02 Biological Activity=15(S)-HEDE is an inhibitor of RBL-1 cell 5-lipoxygenase with an IC50 of 26 mM[[Reference:Haviv_F:Ratajczyk_JD:DeNet_RW:Martin_YC:Dyer_RD:Carter_GW:,J. Med. Chem.,1987,30,254
LBF20207HP01 Biological Activity=Although the biological activities of 15(S)-HpEDE have not been well characterized, it is expected to behave similarly to 15(S)-HpETE.
LBF20207OX01 Biological Activity=15-OxoEDE is produced by the oxidation of 15-HEDE. Some other oxo-eicosanoids have been shown to be biosynthesized and to have potent inflammatory activity [[Reference:Powell_WS:Gravelle_F:Gravel_S:,J. Biol. Chem.,1992,267,19233
LBF20207PG01 Biological Activity=Prostaglandin A1 relaxes uterine muscle and shows hypotensive effects on rat and dog [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1
LBF20207PG22 Biological Activity=Biological significance of prostaglandin D2 was unknown except anti-aggregatory and bronchoconstrictive activities [[Reference:Giles_H:Leff_P:,Prostaglandins,1988,35,277
LBF20207PG23 Biological Activity=Prostaglandin E2 exhibits various biological activities such as vasodilatation, uterine contraction, gastrointestinal contraction, bronchodilatation, diuresis, pyrexia, inhibition of gastric secretion, bone resorption and immunosuppression [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1
LBF20207PG24 Biological Activity=It is well known that the biological activities of various prostaglandins are reduced upon their dehydrogenation at carbon-15 by the catalysis of 15-hydroxyprostaglandin dehydrogenase [[Reference:Anggard_E:,Acta Physiol. Scand.,1966,66,509
LBF20207PG25 Biological Activity=Prostaglandin F2 α exhibits various biological activities such as uterine contraction, gastrointestinal contraction, bronchoconstriction, luteolysis and vasoconstriction [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1
LBF20207PG26 Biological Activity=It is well known that the biological activities of various prostaglandins are reduced upon their dehydrogenation at carbon-15 by the catalysis of 15-hydroxyprostaglandin dehydrogenase [[Reference:Anggard_E:,Acta Physiol. Scand.,1966,66,509
LBF20207PG27 Biological Activity=Prostaglandin G2 is a metabolic intermediate, but the compound as such has biological activities of bronchoconstriction and vasoconstriction [[Reference:Moncada_S:Vane_JR:,Pharmacol. Rev.,1978,30,293
LBF20207PG28 Biological Activity=5-trans PGE2 has 18 times potency in activating adenylate cyclase compared to PGE2.[[Reference:Hensby_CN:MacDermot_J:,Biochem. Soc. Trans.,1979,7,1302
LBF20207PG29 Biological Activity=19(R)-hydroxy PGE2 is a potent smooth muscle relaxant and a selective agonist for the EP2 receptor.[[Reference:Kelly_RW:Taylor_PL:Hearn_JP:Short_RV:Martin_DE:Marston_JH:,Nature,1976,260,544
LBF20207PG34 Biological Activity=11 β -Prostaglandin E2 induces bone resorption at 10-8 ~ 10-6 M in rats.[[Reference:Raisz_LG:Woodiel_FN:,Prostaglandins,1989,37,229
LBF20207PG35 Biological Activity=11-deoxy Prostaglandin E2 shows strong bronchoconstriction of human smooth muscle .[[Reference:Karim_SM:Adaikan_PG:Kottegoda_SR:,Adv. Prostaglandin Thromboxane Leukot. Res.,1980,7,969
LBF20207PG36 Biological Activity= Prostaglandin F2 α 1,11-lactone shows reduction of vasoacitivity and anti-fertility effect.[[Reference:Bundy_GL:Peterson_DC:Cornette_JC:Miller_WL:Spilman_CH:Wilks_JW:,J. Med. Chem.,1983,26,1089
LBF20207PG37 Biological Activity= Prostaglandin F2 α 1,15-lactone terminates pregnancy at early stage.[[Reference:Spilman_CH:Beuving_DC:Forbes_AD:Kimball_FA:,Prostaglandins,1977,14,477
LBF20207PG38 Biological Activity=5-trans Prostaglandin F2 α shows incease of respiratory rate in rabbit.[[Reference:Brookes_LG:Marshall_RC:,J. Pharm. Pharmacol.,1974,26 Suppl,80
LBF20207PG39 Biological Activity= 11-deoxy Prostaglandin F2 α shows smooth muscle contraction effect in rabbit aorta, dog saphenous vein, guinea pig trachea.[[Reference:Jones_RL:Peesapati_V:Wilson_NH:,Br. J. Pharmacol.,1982,76,423
LBF20207PG40 Biological Activity=Prostaglandin F2 β shows bronchodialation effect in guinea pig and cat.[[Reference:Rosenthale_ME:Dervinis_A:Kassarich_J:Blumenthal_A:Gluckman_MI:,Prostaglandins,1973,3,767
LBF20207PG41 Biological Activity=15(R)-PGD2 is reported to have potent agonistic effect to the DP2 receptor 5 time higher than PGD2.[[Reference:Giles_H:Leff_P:Bolofo_ML:Kelly_MG:Robertson_AD:,Br. J. Pharmacol.,1989,96,291
LBF20207PG42 Biological Activity=15(R)-PGE2 is shown to inhibit fertility at a dose of 1.0 mg in hamsters.[[Reference:Miller_WL:Sutton_MJ:,Prostaglandins,1976,11,77
LBF20207PG43 Biological Activity=8-iso PGE2 inhibits U-46619 or I-BOP-induced platelet aggregation with IC50 values of 0.5 and 5 μ M.[[Reference:Longmire_AW:Roberts_LJ:Morrow_JD:,Prostaglandins,1994,48,247
LBF20207PG44 Biological Activity=PGF2 α Alcohol is reported to retain ocular hypotensive properties , but the target receptor is not cleared yet.[[Reference:Woodward_DF:Krauss_AH:Chen_J:Gil_DW:Kedzie_KM:Protzman_CE:Shi_L:Chen_R:Krauss_HA:Bogardus_A_et_al:,Br. J. Pharmacol.,2000,130,1933
LBF20207PG45 Biological Activity=In hamster antifertility study, 15(R)-PGF2 α is reported quarter potency of PGF2 α , which is due to reduced affinity to FP receptors.[[Reference:Miller_WL:Sutton_MJ:,Prostaglandins,1976,11,77
LBF20207PG46 Biological Activity=8-iso PGF2 α is reported to inhibit platelet aggregation induced by U-46619 (1 μ M) and I-BOP (0.3 μ M) with IC50 of 1.6 μ M and 1.8 μ M, respectively.[[Reference:Morrow_JD:Minton_TA:Roberts_LJ:2nd:,Prostaglandins,1992,44,155
LBF20207PG47 Biological Activity=In vasoconstriction studies, 8-iso-15-keto PGF2 α has been reported as a member of vasoconstrictor on the rat isolated thoracic aorta through TP receptor.[[Reference:Cracowski_JL:Camus_L:Durand_T:Devillier_P:Guy_A:Hardy_G:Stanke-Labesque_F:Rossi_JC:Bessard_G:,J. Cardiovasc. Pharmacol.,2002,39,396
LBF20207PG48 Biological Activity=8-iso PGF2 β has been reported to show very weak contraction of human umbilical vein artery and does not promote aggregation of human whole blood.[[Reference:Oliveira_L:Stallwood_NA:Crankshaw_DJ:,Br. J. Pharmacol.,2000,129,509
LBF20207PG49 Biological Activity=PGH2 was firstly reported as a potent vasoconstrictor.[[Reference:Hamberg_M:Svensson_J:Wakabayashi_T:Samuelsson_B:,Proc. Nat. Acad. Sci. USA,1974,71,345
LBF20207PG51 Biological Activity=Prostaglandin I2 is a potent anti-aggregatory agent for platelets, relaxes blood vessels, and enhances vascular permeability [[Reference:Whittle_BJ:Moncada_S:,Br. Med. Bull.,1983,39,232
LBF20207PG52 Biological Activity=15(R)-PGF2 α has only quarter of the ability of PGF2 α in hamster antifertility studies[[Reference:Miller_WL:Sutton_MJ:,Prostaglandins,1976,11,77
LBF20207PG53 Biological Activity=15(S)-15-methyl Prostaglandin D2 is reported to inhibit ADP-induce human platelet aggregation (IC50 value of 320 ng/ml) and increase systemic blood pressure in rat. [[Reference:Bundy_GL:Morton_DR:Peterson_DC:Nishizawa_EE:Miller_WL:,J. Med. Chem.,1983,26,790
LBF20207PG54 Biological Activity=9-deoxy-9-methylene Prostaglandin E2 decreases blood pressure in rat and [[Reference:Bundy_GL:Kimball_FA:Robert_A:Aiken_JW:Maxey_KM:Sebek_OK:Nelson_NA:Sih_JC:Miller_WL:Hsi_RS:,Adv. Prostaglandin Thromboxane Leukot. Res.,1980,6,355
LBF20207PG55 Biological Activity=15(R)-15-methyl Prostaglandin E2 shows increase of bicarbonate secretion in duodenum and inhibition of gastric acid secretion.[[Reference:Takanashi_H:Itoh_Z:,Jpn. J. Pharmacol.,1991,57,447
LBF20207PG56 Biological Activity=15(S)-15-methyl Prostaglandin E2 inhibits gastric acid secretion and consequent ulcer formation.[[Reference:Kimball_FA:Kirton_KT:Spilman_CH:Wyngarden_LJ:,Biol Reprod.,1975,13,479
LBF20207PG57 Biological Activity=Prostaglandin F2 α Alcohol methyl ether shows hypotensive effect in ocular.[[Reference:Woodward_DF:Chan_MF:,Chem._Abstr.,2003,,38204
LBF20207PG58 Biological Activity=Intramuscularly injection of 15(S)-15-methyl Prostaglandin F2 α induce abortion.[[Reference:Lindblom_B:Hahlin_M:Kallfelt_B:Hamberger_L:,Lancet,1987,1,776
LBF20207PG59 Biological Activity=11-deoxy-11-methylene PGD2 has been reported to be essentially without agonist activity on human platelets, a DP receptor assay.[[Reference:Torisawa_Y:Yamaguchi_T:Sakata_S:,Chem. Pharm. Bull. (Tokyo),1985,33,4625
LBF20207PG60 Biological Activity=PGD2 has been reported to have two receptors, DP1 and CRTH2. The latter was recently identified on human eosinophils, and 11-deoxy-11methylene-15-keto PGD2 ischemically stable ligand for this receptor.[[Reference:Hirai_H:Tanaka_K:Yoshie_O:Ogawa_K:Kenmotsu_K:Takamori_Y:Ichimasa_M:Sugamura_K:Nakamura_M:Takano_S_et_al:,J. Exp. Med.,2001,193,255
LBF20207PG61 Biological Activity=15(R)-15-methyl PGD2 is reported as a potent selective agonist for the DP2 and CRTH2 and induce CD11b expression, actin polymerization, and chemotaxis in eosinophyils.[[Reference:Monneret_G:Cossette_C:Gravel_S:Rokach_J:Powell_WS:,J. Pharmacol. Exp. Ther.,2003,304,349
LBF20207PG62 Biological Activity=PGF2 α methyl ester is reported to have higher ocular hypotensive activity than PGF2 α with application to eyes of cats at 2.5 μ g of dose.[[Reference:Bito_LZ:,Exp. Eye Res.,1984,38,181
LBF20207PG63 Biological Activity=15(R)-15-methyl PGF2 α is converted into the active 15(S)-isomer, which induce luteolysis after injection in rhesus monkeys at a dose of 12 mg/animal.[[Reference:Wilks_JW:,Prostaglandins,1980,20,793
LBF20207PG65 Biological Activity= 16,16-dimethyl Prostaglandin D2 enhances ADP-induce human platelet aggregation and increase systemic blood pressure in rat. [[Reference:Bundy_GL:Morton_DR:Peterson_DC:Nishizawa_EE:Miller_WL:,J. Med. Chem.,1983,26,790
LBF20207PG66 Biological Activity= In rat, 11-deoxy-16,16-dimethyl Prostaglandin E2 inhibits secretion of gastric acid secretion so that suppresses ulcer formation.[[Reference:Lippmann_W:,Prostaglandins,1974,7,231
LBF20207PG67 Biological Activity= 16,16-dimethyl Prostaglandin E2 shows cervical ripening and uterine constriction and consequent inhibition of ulcer formation.[[Reference:Robert_A:Schultz_JR:Nezamis_JE:Lancaster_C:,Gastroenterology,1976,70,359
LBF20207PG68 Biological Activity=Prostaglandin F2 α dimethyl amide shows inhibition of PGF2 α -induced contraction in gerbil colon.
LBF20207PG69 Biological Activity=Prostaglandin F2 α Ethanolamide shows dialation effect in cat iris sphincter.
LBF20207PG70 Biological Activity= 16,16-dimethyl Prostaglandin F2 β reduce asthmatic bronchospasm.[[Reference:Allegra_L:Bianco_S:,Prog. Resp. Res. ,1980,14,215
LBF20207PG71 Biological Activity=PGF2 &α; is shown to inhibit the contractile effects of PGF2 &α; by 60% at 6 ng/ml.[[Reference:Maddox_YT:Ramwell_PW:Shiner_CS:Corey_EJ:,Nature,1978,273,549
LBF20207PG72 Biological Activity=15(S)-15methyl PGF2 α methylester is hydrolysed in vivo to 15(S)-15-methyl PGF2 α shown as a potent uterine stimulant and abortifacient.
LBF20207PG74 Biological Activity= 9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 shows term dependent termination of pregnant in conbination with other PGs.[[Reference:Wilks_JW:,Science,1983,221,1407
LBF20207PG75 Biological Activity=Prostaglandin F2 α isopropyl ester is easily hydrolyzed into PGF2 α and reduces intraocular pressure after admiration into eyes.[[Reference:Crawford_KS:Kaufman_PL:,Invest. Ophthalmol. Vis. Sci.,1991,32,510
LBF20207PG79 Biological Activity= 16,16-dimethyl Prostaglandin A1 shows inhibition against infection of HSV and HIV-1 at the ID50 of 3.8-7.3 and 2.5 μ g/ml respectively. [[Reference:Hughes-Fulford_M:McGrath_MS:Hanks_D:Erickson_S:Pulliam_L:,Antimicrob. Agents Chemother.,1992,36,2253
LBF20207TX01 Biological Activity=Thromboxane A2 aggregates platelets and constricts blood vessels and bronchi [[Reference:Whittle_BJ:Moncada_S:,Br. Med. Bull.,1983,39,232
LBF20207TX02 Biological Activity=Thromboxane B2 as s stable degradation product of thromboxane A2 shows diminishd biological activity [[Reference:Whittle_BJ:Moncada_S:,Br. Med. Bull.,1983,39,232
LBF20208PG01 Biological Activity= δ 12-PGD2 is catalyzed to δ 12-PGJ2, which has antimitotic and carcinogenic activities.[[Reference:Kato_T:Fukushima_M:Kurozumi_S:Noyori_R:,Cancer Res.,1986,46,3538
LBF20212LT01 Biological Activity=unknown
LBF20303PG03 Biological Activity=As presented in Table 1 of reference [[Reference:Bergstrom_S:Carlson_LA:Weeks_JR:,Pharmacol. Rev.,1968,20,1
LBF20303PG05 Biological Activity=PGD3 has almost same ability to decrease systemic blood pressure in rats and to decrease intraocular pressure in rabbits.[[Reference:Bundy_GL:Morton_DR:Peterson_DC:Nishizawa_EE:Miller_WL:,J. Med. Chem.,1983,26,790
LBF20303PG06 Biological Activity=PGI3 has equal ability to PGI2 in inhibitting human platelet aggregation.[[Reference:Mann_NJ:Warrick_GE:ODea_K:Knapp_HR:Sinclair_AJ:,Lipids,1994,29,157
LBF20303PG07 Biological Activity=There is only one report on 8-iso PGF3 α showing inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2 α has an ED50 value of 1 μ M.[[Reference:Pratico_D:Smyth_EM:Violi_F:FitzGerald_GA:,J. Biol. Chem.,1996,271,14916
LBF20303TX01 Biological Activity=Thromboxane A3 did not cause platelet aggregation unlike thromboxane A2, and inhibited platelet aggregation by other agonists [[Reference:Needleman_P:Raz_A:Minkes_MS:Ferrendelli_JA:Sprecher_H:,Proc. Natl. Acad. Sci. U. S. A.,1979,76,944
LBF20306CV03 Biological Activity=10,11-Epoxychlorovulone I showed the strong antiproliferative and cytotoxic activities in himan promyelocytic leukemia (HL-60) ((IC50 0.04 μ g/ml, cytotoxic effect >0.3 μ g/ml).[[Reference:Honda_A:Mori_Y:Iguchi_K:Yamada_Y:,Prostaglandins,1988,36,621
LBF20306EO01 Biological Activity=In neuroendocrine cells such as the anterior pituitary and pancreatic islet, (±)5(6)-EpETrE has been implicated in the mobilization of Ca 2+ and hormone secretion [[Reference:Snyder_G:Lattanzio_F:Yadagiri_P:Falck_JR:Capdevila_J:,Biochem. Biophys. Res. Commun.,1986,139,1188
LBF20306EO02 Biological Activity=(±)8(9)-EpETrE reduces the glomerular filtration rate (GFR) through cyclooxygenase-dependent preglomerular vasoconstriction [[Reference:Katoh_T:Takahashi_K:Capdevila_J:Karara_A:Falck:JR:Jacobson:HR:Badr:KF:,Am. J. Physiol.,1991,261,F578
LBF20306EO03 Biological Activity=(±)11(12)-EpETrE has been shown, along with (±)8(9)-EpETrE, to play a role in the recovery of depleted Ca2+ pools in cultured smooth muscle cells [[Reference:Graber_MN:Alfonso_A:Gill_DL:,J. Biol. Chem.,1997,272,29546
LBF20306HO02 Biological Activity=Epoxide hydrolases convert the EpETrEs into vicinal diols[[Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771
LBF20306HO07 Biological Activity=The compound has vasodilatory activity, and may be involved in the wound-healing of corneal injury [[Reference:Murphy_RC:Falck_JR:Lumin_S:Yadagiri_P:Zirrolli_JA:Balazy_M:Masferrer_JL:Abraham_NG:Schwartzman_ML:,J. Biol. Chem.,1988,263,17197
LBF20306HX03 Biological Activity=As the biological activities of hepoxilin A3, insulin secretion from pancreas is stimulated, the enhanced vascular permeability by bradykinin is potentiated, hyperpolarization in hippocampal CA1 neurons is caused, and platelet aggregation is inhibited. At the molecular level hepoxilin A3 releases intracellular calcium, and opens potassium channel. Hepoxilin-specific binding proteins are present in human neutrophils [[Reference:Pace-Asciak_CR:,Biochim. Biophys. Acta,1994,1215,1
LBF20306HX04 Biological Activity=Little has been described about the biological actvity of hepoxilin B3 except for its poteniation of glucose-dependent insulin secretion [[Reference:Pace-Asciak_CR:,Biochim. Biophys. Acta,1994,1215,1
LBF20306PG01 Biological Activity= 15-deoxy- Δ 12.14-Prostaglandin D2 shows cytotoxity on murine leukemia cell line (IC50 value of 0.3 μ g/ml).[[Reference:Corey_EJ:Cyr_CR:,Tetrah. Lett.,1974,,1761
LBF20307HO01 Biological Activity=Compared to a series of hydroxypolyenoic fatty acids, 15(S)-HETrE is a more potent inhibitor of human 5-lipoxygenase from polymorphonuclear leukocytes having an IC50 of 4.6 &μ; M at an arachidonic acid concentration of 5 &μ; M [[Reference:Petrich_K:Ludwig_P:Kuhn_H:Schewe_T:,Biochem. J.,1996,314 (Pt 3),911
LBF20307PG01 Biological Activity=Antitumor activity of prostaglandin A2 is known [[Reference:Fukushima_M:,Eicosanoids,1990,3,189
LBF20307PG02 Biological Activity=19-Hydroxy-prostaglandin A2 relaxes uterine myometriuim [[Reference:Horton_EW:,Physiol. Rev.,1969,49,122
LBF20307PG04 Biological Activity=19-Hydroxy-prostaglandin B2 relaxes uterine myometriuim [[Reference:Horton_EW:,Physiol. Rev.,1969,49,122
LBF20307PG06 Biological Activity= 16,16-dimethyl Prostaglandin A2 shows inhibitory effect on the proliferation of Sendai virus in monkey cells.[[Reference:Tanaka_T:Hazato_A:Bannai_K:Okamura_N:Sugiura_S:Manabe_K:Toru_T:Kurozumi_S:Suzuki_M:Kawagishi_T_et_al:,Tetrahedron,1987,43,813
LBF20307PG38 Biological Activity=The anti-tumor and anti-viral activities of prostaglandin J2 are attributed to Δ 12-prostaglandin J2 which is a degradation product of prostagladnin J2 and is characteristic of its alkylidene cyclopentenone structure [[Reference:Fukushima_M:,Prostaglandins Leukot. Essent. Fatty Acids,1992,47,1
LBF20308PG01 Biological Activity= Δ 12-PGJ2 has antitumor and antibiral activity, inhibiting growth of cultured L1210 cells with an IC50 of 0.7 μ g/ml.[[Reference:Kato_T:Fukushima_M:Kurozumi_S:Noyori_R:,Cancer Res.,1986,46,3538
LBF20308PG03 Biological Activity= Δ 12-Prostaglandin J2 is considered to be an ultimate metabolite of prostaglandin D2 with anti-tumor and anti-viral activities [[Reference:Narumiya_S:Fukushima_M:,Biochem. Biophys. Res. Commun.,1985,127,739
LBF20406AM01 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CBl),Ki(nM)>10000[[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM02 Biological Activity=Binding of this compoud to the brain cannabinoid receptor (CBl), Ki(nM)>10000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM03 Biological Activity=Binding of this compound to the brain cannabinoid receptor(CB1),Ki(nM)>10000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM04 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CB1), Ki (nM)= 34.0±2.7 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM05 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CB1),Ki(nM)= 60.0±7.4 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM06 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CBl),Ki (nM)>1000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM07 Biological Activity=Binding of this compound to the rat brain cannabinoid receptor (CBl), Ki= 11.7±2.1 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM08 Biological Activity=Binding of this compound to the rat brain cannabinoid receptor (CBl), Ki (nM)= 13.6±1.1[[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM09 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CB1),Ki (nM)= 235.7±l4.2 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM10 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CBl),Ki(nM)>1000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM11 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CBl),Ki(nM)>l000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM12 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CBl),Ki(nM)= 575.1±35.3 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM13 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CBl),Ki(nM)= 446.7±40.3 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM14 Biological Activity=Binding to the brain cannabinoid receptor (CBl),Ki(nM)= 239.9±63.8 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM15 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 377.2±55.4 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM16 Biological Activity=Binding to the brain cannabinoid receptor (CBl),Ki(nM)= 29.9±0.4[[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM17 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 161.8±34.1 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM18 Biological Activity=Binding to the rat brain cannabinoid receptor (CBl), Ki(nM)= 497.4±27.1 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM19 Biological Activity=Binding to the rat brain cannabinoid receptor (CBl), Ki(nM)= 85.2±3.8 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM20 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)>1000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM21 Biological Activity=Binding to the rat brain cannabinoid receptor (CBl), Ki(nM)>1000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM22 Biological Activity=Binding to the rat brain cannabinoid receptor (CBl), Ki(nM)>1000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM23 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)>10000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM24 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)>10000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM25 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)>10000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM26 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki>10000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM27 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki (nM)>1000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM28 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 32.5±5.1 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM29 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 25.5±2.8 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM30 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 7.4±0.2 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM31 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 6.9±0.7 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM32 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 8.4±1.1 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM33 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 7.2±0.1 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM34 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 46.6±2.2 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM35 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)= 3l.l±1.0 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM36 Biological Activity=binding to the brain cannabinoid receptor (CBl), Ki(nM)= 191.4±24.5 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM37 Biological Activity=[[:Template:Image200
LBF20406AM38 Biological Activity=[[:Template:Image200
LBF20406AM39 Biological Activity=Binding to the brain cannabinoid receptor(CBl), Ki(nM)= 153.9±30.0 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM40 Biological Activity=[[:Template:Image200
LBF20406AM41 Biological Activity=[[:Template:Image200
LBF20406AM42 Biological Activity=Binding to the brain cannabinoid receptor (CBl), Ki(nM)>1000 [[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406AM43 Biological Activity=[[:Template:Image200
LBF20406AM44 Biological Activity=[[:Template:Image200
LBF20406AM45 Biological Activity=[[:Template:Image200
LBF20406AM46 Biological Activity=[[:Template:Image200
LBF20406CV05 Biological Activity=Clavulones showed a significant anti-inflammatory effect at 30 μ g/ml by the fertile egg test.[[Reference:Kikuchi_H:Tsukitani_Y:Iguchi_K:Yamada_Y:,Tetrahedron Lett.,1982,23,5171
LBF20406CV06 Biological Activity=Clavulones showed a significant anti-inflammatory effect at 30 μ g/ml by the fertile egg test.[[Reference:Kikuchi_H:Tsukitani_Y:Iguchi_K:Yamada_Y:,Tetrahedron Lett.,1982,23,5171
LBF20406CV07 Biological Activity=Clavulones showed a significant anti-inflammatory effect at 30 μ g/ml by the fertile egg test.[[Reference:Kikuchi_H:Tsukitani_Y:Iguchi_K:Yamada_Y:,Tetrahedron Lett.,1982,23,5171
LBF20406CV08 Biological Activity=Clavulones showed a significant anti-inflammatory effect at 30 μ g/ml by the fertile egg test.[[Reference:Kikuchi_H:Tsukitani_Y:Iguchi_K:Yamada_Y:,Tetrahedron Lett.,1982,23,5171
LBF20406CV09 Biological Activity=20-Acetoxyclavulones showed a significant anti-inflammatory effect at 30 μ g/ml by the fertile egg test.[[Reference:Kikuchi_H:Tsukitani_Y:Iguchi_K:Yamada_Y:,Tennen Yuki Kagoubutsu Toronkai Koen Yoshishu 26th,1983,26,220
LBF20406CV10 Biological Activity=20-Acetoxyclavulones showed a significant anti-inflammatory effect at 30 μ g/ml by the fertile egg test.[[Reference:Kikuchi_H:Tsukitani_Y:Iguchi_K:Yamada_Y:,Tennen Yuki Kagoubutsu Toronkai Koen Yoshishu 26th,1983,26,220
LBF20406CV11 Biological Activity=20-Acetoxyclavulones showed a significant anti-inflammatory effect at 30 μ g/ml by the fertile egg test.[[Reference:Kikuchi_H:Tsukitani_Y:Iguchi_K:Yamada_Y:,Tennen Yuki Kagoubutsu Toronkai Koen Yoshishu 26th,1983,26,220
LBF20406CV12 Biological Activity=Chlorovulone I showed the strong antiproliferative and cytotoxic activities in himan promyelocytic leukemia (HL-60) ((IC50 0.01 μ g/ml, cytotoxic effect >0.1 μ g/ml).[[Reference:Honda_A:Mori_Y:Iguchi_K:Yamada_Y:,Prostaglandins,1988,36,621
LBF20406CV13 Biological Activity=(-)-Chlorovulone II showed the strong antiproliferative and cytotoxic activities in himan promyelocytic leukemia (HL-60) ((IC50 0.01 μ g/ml, cytotoxic effect >0.1 μ g/ml).[[Reference:Honda_A:Mori_Y:Iguchi_K:Yamada_Y:,Mol. Pharmacol.,1987,32,530
LBF20406CV16 Biological Activity=Bromovulone I showed the strong antiproliferative and cytotoxic activities in himan promyelocytic leukemia (HL-60) ((IC50 0.025 μ g/ml, cytotoxic effect >0.4 μ g/ml).[[Reference:Honda_A:Mori_Y:Iguchi_K:Yamada_Y:,Prostaglandins,1988,36,621
LBF20406CV17 Biological Activity=Iodovulone I showed the strong antiproliferative and cytotoxic activities in himan promyelocytic leukemia (HL-60) ((IC50 0.06 μ g/ml, cytotoxic effect >0.4 μ g/ml).[[Reference:Honda_A:Mori_Y:Iguchi_K:Yamada_Y:,Prostaglandins,1988,36,621
LBF20406HO07 Biological Activity=5(S),6(R)-DiHETE is a weak LTD 4 receptor agonist in guinea pig lung membranes[[Reference:Muller_A:Rechencq_E:Kugel_C:Lellouche_JP:Beaucourt_JP:Niel_G:Girard_JP:Rossi_JC:Bonne_C:,Prostaglandins,1989,38,635
LBF20406HO08 Biological Activity=5(S),6(S)-DiHETE does not have a significant leukotriene-like activity[[Reference:Oliw_EH:Guengerich_FP:Oates_JA:,J. Biol. Chem.,1982,257,3771
LBF20406HO09 Biological Activity=3(R)-HETE enhances the formation of platelet activating factor and release of arachidonic acid from human neutrophils .
LBF20406HO10 Biological Activity=5(R)-HETE is a potent chemotactic agent. 5(R)-HETE induces human neutrophil migration across cellular and noncellular barriers in a dose- and time-dependent fashion, whereas 5(S)-HETE is inactive. [[Reference:Bittleman_DB:Casale_TB:,Am. J. Respir. Cell Mol. Biol.,1995,12,260
LBF20406HO11 Biological Activity=5(S)-HETE is incorporated specifically into phosphatidylcholine and glycerol esters causing the inhibition of prostaglandin I2 and E2 synthesis in histamine or arachidonic acid stimulated human endothelial cells [[Reference:Richards_CF:Johnson_AR:Campbell_WB:,Biochim. Biophys. Acta,1986,875,569
LBF20406HO12 Biological Activity=8(R)-HETE induces maturation of starfish oocytes at a concentration of 0.071 &μ; M [[Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040
LBF20406HO13 Biological Activity=Both 8(S)- and 8(R)-HETEs activate mouse skin protein kinase C at a dose of 100 &μ; M[[Reference:Hughes_MA:Brash_AR:,Biochim. Biophys. Acta,1991,1081,347
LBF20406HO16 Biological Activity=11(R)-HETE has been associated with sea urchin fertilization and/or maturation, as well as hydroid tentacle regeneration [[Reference:Hawkins_DJ:Brash_AR:,J. Biol. Chem.,1987,262,7629
LBF20406HO18 Biological Activity=12(R)-HETE is the primary lipoxygenase product in invertebrates such as the sea urchin where it plays a role in reproduction physiology [[Reference:Hawkins_DJ:Brash_AR:,J. Biol. Chem.,1987,262,7629
LBF20406HO21 Biological Activity=There are reports for various biological activities of 12(S)-hydroxy acid such as rat hypothalamic secretion of LH-RH, stimulated chemotactic activity of human eosinophils and neutrophils, stimulated migration of epidermal tumor cells and rat aortic smooth muscle cells, involvement in angiotension II-mediated aldosterone biosynthesis in human adrenal glomerulosa, and expression or activation of GpIIb/IIIa in tumor cells, but a general theory has not been established [[Reference:Yamamoto_S:Suzuki_H:Ueda_N:,Prog. Lipid Res.,1997,36,23
LBF20406HO22 Biological Activity=The compound is involved in the maturation of starfish oocyte [[Reference:Meijer_L:Brash_AR:Bryant_RW:Ng_K:Maclouf_J:Sprecher_H:,J. Biol. Chem.,1986,261,17040
LBF20406HO23 Biological Activity=12(S)-HETE enhances tumor cell adhesion to endothelial cells, subendothelial matrix, and fibronectin but not to type IV collagen at the concentration of 0.01 &μ; M to 0.1 &μ; M [[Reference:Grossi_IM:Fitzgerald_LA:Umbarger_LA:Nelson_KK:Diglio_CA:Taylor_JD:Honn_KV:,Cancer Res.,1989,49,1029
LBF20406HP01 Biological Activity=5-HPETE generated by 5-lipoxygenase is enzymatically converted to bioactive compounds such as leukotriene and HETE[[Reference:Spector_AA:Gordon_JA:Moore_SA:,Prog. Lipid Res.,1988,27,271
LBF20406HP02 Biological Activity=8-HPETE generated by 8-lipoxygenase is enzymatically converted to bioactive compounds such as leukotriene and HETE.
LBF20406HP03 Biological Activity=9-HPETE generated by 9-lipoxygenase is enzymatically converted to bioactive compounds such as leukotriene and HETE.
LBF20406HP04 Biological Activity=12-HPETE generated by 12-lipoxygenase is enzymatically converted to bioactive compounds such as leukotriene and HETE[[Reference:Spector_AA:Gordon_JA:Moore_SA:,Prog. Lipid Res.,1988,27,271
LBF20406HP05 Biological Activity=15-HPETE generated by 15-lipoxygenase is enzymatically converted to bioactive compounds such as leukotriene and HETE[[Reference:Spector_AA:Gordon_JA:Moore_SA:,Prog. Lipid Res.,1988,27,271
LBF20406HP10 Biological Activity=11-HPETE generated by 11-lipoxygenase is enzymatically converted to bioactive compounds such as leukotriene and HETE[[Reference:Spector_AA:Gordon_JA:Moore_SA:,Prog. Lipid Res.,1988,27,271
LBF20406LT01 Biological Activity=Leukotriene A4 as such is biologically less active than its active metabolites, leukotrienes B4 and C4. For example, leukotriene A4 is at least two orders of magnitude less potent than leukotrienes C4, D4 and E4 in contraction of guinea pig lung strips [[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355
LBF20406LT02 Biological Activity=Leukotriene B4 causes adhesion of leukocytes to endothelial cells, stimulates chemotaxis and chemokinesis of leukocytes[[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355
LBF20406LT03 Biological Activity=Increase in intracellular calcium in human leukocytes probably through BLT (LTB4 receptor). The IC 50 value is 100 times higher than that of LTB4.
LBF20406LT04 Biological Activity=Leukotriene B4 dimethylamide inhibits LTB4 induced degranulation of human neutrophils at the concentration of 130 nM (Ki) and release of lysozyme of PMNL.[[Reference:Falcone_RC:Aharony_D:,J. Pharmacol. Exp. Ther.,1990,255,565
LBF20406LT05 Biological Activity=LTB4-EA is reported as a potent antagonist about 3 fold higher affinity for the human LTB4 receptor that LTB4. And LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with 10 nM as an EC50.[[Reference:McHugh_D:McMaster_S:Ross_R:,13th_Annual_ICRS_Cannabinoid_Symposium,2003,,121
LBF20406LT06 Biological Activity=6-trans LTB4 is reported as a chemoattractant to neutrophils but the properties is relatively weal compared with LTB4.[[Reference:Fretland_DJ:Widomski_DL:Anglin_CP:Walsh_RE:Levin_S:Gaginella_TS:,J. Leukoc. Biol.,1991,49,283
LBF20406LT07 Biological Activity=6-trans-12-epi LTB4 is reported as a weak chemotactic factors for PMNL with 20 times less potency thant LTB4 .[[Reference:Lee_TH:Menica-Huerta_JM:Shih_C:Corey_EJ:Lewis_RA:Austen_KF:,J. Biol. Chem.,1984,259,2383
LBF20406LT08 Biological Activity=12-epi LTB4 has a week agonistic character at both recombinant human BLT1 and BLT2 approximately 10 Mfor complete activation.[[Reference:Yokomizo_T:Kato_K:Hagiya_H:Izumi_T:Shimizu_T:,J. Biol. Chem.,2001,276,12454
LBF20406LT09 Biological Activity=The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degradation.[[Reference:Feinmark_SJ:Lindgren_JA:Claesson_HE:Malmsten_C:Samuelsson_B:,FEBS Lett.,1981,136,141
LBF20406LT10 Biological Activity=14,15-dehydro LTB4 is reported as a selective ligand for the BLT1 and act as a selective antagonist of LTB4 in vivo.[[Reference:Wang_S:Gustafson_E:Pang_L:Qiao_X:Behan_J:Maguire_M:Bayne_M:Laz_T:,J. Biol. Chem.,2000,275,40686
LBF20406LT11 Biological Activity=20-hydroxy LTB4 is commonly accepted as a inactive metabolite of LTB4 but reported to contract parenchymal strips from guinea pig lung [[Reference:Hansson_G:Lindgren_JA:Dahlen_SE:Hedqvist_P:Samuelsson_B:,FEBS Lett.,1981,130,107
LBF20406LT12 Biological Activity=20-trifluoro LTB4 has equal chemotactic activity to LTB4 with an EC50 of 3 nM [[Reference:Tsai_BS:Keith_RH:Villani-Price_D:Haack_RA:Bauer_RF:Leonard_R:Abe_Y:Nicolaou_KC:,Prostaglandins,1989,37,287
LBF20406LT13 Biological Activity=Leukotriene D4 stimulates airway smooth muscles and causes bronchoconstriction. Vascular permeability is enhanced. Gasstrointestinal smooth muscles are contracted [[Reference:Samuelsson_B:Hammarstrom_S:,Vitam. Horm.,1982,39,1
LBF20406LT14 Biological Activity=Leukotriene C4 is a potent stimulator of airway smooth muscles and causes bronchoconstriction as demonstrated in vitro and in vivo experiments, and gastrointestinal smooth muscles are also contracted. Vascular permeability is enhanced by leukotriene C4 at concentrations lower by 3-4 orders of magnitude than histamine [[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355
LBF20406LT15 Biological Activity=The contraction effect on guinea pig parenchymal and ileum is almost equal to LTC4.[[Reference:Dahlen_SE:Hedqvist_P:Hammarstrom_S:,Eur. J. Pharmacol.,1982,86,207
LBF20406LT16 Biological Activity=The potency for contraction of guinea pig ileum, trachea, and parenchyma of 11-trans LTD4 is 10-25% compared to LTD4.[[Reference:Baker_SR:Boot_JR:Jamieson_WB:Osborne_DJ:Sweatman_WJ:,Biochem. Biophys. Res. Commun.,1981,103,1258
LBF20406LT17 Biological Activity=Leukotriene E4 stimulates airway smooth muscles from different animal species, and is less potent than C4 in contracting isolated guinea pig ileum [[Reference:Hammarstrom_S:,Annu. Rev. Biochem.,1983,52,355
LBF20406LT18 Biological Activity=11-trans LTE4 has equal potency to LTE4 in contracting guinea pig ileum.[[Reference:Hammarstrom_S:Orning_L:Bernstrom_K:,Mol. Cell. Biochem.,1985,69,7
LBF20406OX01 Biological Activity=It stimulates cytosolic calcium levels in neutrophils with an EC of 2 nM [[Reference:Powell_WS:Zhang_Y:Gravel_S:,Biochemistry,1994,33,3927
LBF20406OX02 Biological Activity=12-OxoETE induces a rapid, dose related increase of cytoplasmic free calcium via a leukotriene B4 receptor or a common activation sequence [[Reference:Naccache_PH:Leblanc_Y:Rokach_J:Patrignani_P:Fruteau_de_Laclos_B:Borgeat_P:,Biochim. Biophys. Acta,1991,1133,102
LBF20406PG02 Biological Activity= 15-deoxy- Δ 12.14-Prostaglandin J2 induces lipogenesis and adipocyte differentiation in cultured cell line.[[Reference:Kliewer_SA:Lenhard_JM:Willson_TM:Patel_I:Morris_DC:Lehmann_JM:,Cell,1995,83,813
LBF20406PH01 Biological Activity=Binding of this compound to the brain cannabinoid receptor (CBl),Ki(nM)= 190.8±11.1[[Reference:Sheskin_T:Hanus_L:Slager_J:Vogel_Z:Mechoulam_R:,J. Med. Chem.,1997,40,659
LBF20406SC01 Biological Activity=There are two groups of essential fatty acids, the n-6 (or ω 6) and the n-3 (or ω 3). Arachidonic acid is n-6 fatty acids. Essential fatty acid deficiency causes skin lesion and growth retardation. Dietary supplementation of either linoleate, γ -linoleate or arachidonate prevents such symptoms completely. The n-6 essential fatty acids have at least four roles [[Reference:Horrobin_DF:,Prog. Lipid Res.,1992,31,163
LBF20407HO02 Biological Activity=5(S),15(S)-DiHETE potentiates the degranulation of human polymorphonuclear leukocytes in response to platelet activating factor, but not f-Met-Leu-Phe, calcium ionophore A23187, or Leukotriene B 4 [[Reference:OFlaherty_JT:Thomas_MJ:,Prostaglandins Leukot. Med.,1985,17,199
LBF20407HO04 Biological Activity=8(S),15(S)-diHETE causes chemotaxis of human eosinophils with an ED 50 of 1.5 &μ; M but is not chemotactic for neutrophils [[Reference:Morita_E:Schroder_JM:Christophers_E:,J. Immunol.,1990,144,1893
LBF20407HO06 Biological Activity=15(S)-HETE is a potent inflammatory mediator and agonist of tracheal mucus secretions [[Reference:Ramis_I:Rosello-Catafau_J:Bulbena_O:Picado_C:Gelpi_E:,J. Chromatogr.,1989,496,416
LBF20407HO07 Biological Activity=In connection with biological activities of 15-hydroxyeicosatetraenoic acid, there are reports for pain response of skin, mucus secretion in airway, histamine hypersensitivity, prolactin secretion, and regulation of protein phosporylation and cell signalling [[Reference:Kuhn_H:Thiele_BJ:,J. Lipid Mediat. Cell Signal.,1995,12,157
LBF20407LX01 Biological Activity=LXA is equipotent to LTB in inducing superoxide generation in human neutrophils (0.1 μ M) [[Reference:Serhan_CN:Hamberg_M:Samuelsson_B:,Proc. Natl. Acad. Sci. U. S. A.,1984,81,5335
LBF20408LX01 Biological Activity=It is associated with several biological functions including leukocyte activation, natural killer cell inhibition, and monocyte migration and adhesion [[Reference:Ramstedt_U:Serhan_CN:Nicolaou_KC:Webber_SE:Wigzell_H:Samuelsson_B:,J. Immunol.,1987,138,266
LBF20503HO01 Biological Activity=(±)8-HEPE causes barnacle eggs to hatch with an IC50 = 2.4 x 10-6 M [[Reference:Shing_TKM:Gibson_KH:Wiley_JR:Watt_lF:,Tetrahedron Lett.,1994,35,1067
LBF20503HO02 Biological Activity=At a 10 nM concentration, 8(S)-HEPE causes the eggs of the barnacle, E. modestus to hatch . (±)8-HETE, derived from arachidonic acid, was ineffective in egg hatching .
LBF20503HO03 Biological Activity=Almost all hydroxy-polyunsaturated fatty acids have been implicated in inflammatory reactions in humans. However, there have not been reports specifying the biological activity of 9(S)-HEPE.
LBF20503HO05 Biological Activity=Almost all hydroxy-polyunsaturated fatty acids have been implicated in inflammatory reactions in humans. However, there have not been reports specifying the biological activity of 11(S)-HEPE.
LBF20503HO06 Biological Activity=The biological activity of 12(R)-HEPE has not been extensively documented, but may be similar to that of 12(R)-HETE [[Reference:Masferrer_JL:Dunn_MW:Schwartzman_ML:,Invest. Ophthalmol. Vis. Sci.,1990,31,535
LBF20503HO08 Biological Activity=15(S)-HEPE generated by soybean lipoxygenation of EPA inhibits RBL-1 cell 5-lipoxygenase with an IC50 of 28 mM[[Reference:Miller_C:Yamaguchi_RY:Ziboh_VA:,Lipids,1989,24,998
LBF20503HP01 Biological Activity=5-Hydroperoxide derivative of icosapentaenoic acid, which is produced concomitantly with action of 15-lipoxygenase against arachidonate, is further metabolized to hydroxylate and leukotrienes, but their physiological activities remain to be clarified[[Reference:Lee_TH:Drazen_JM:Lewis_RA:Austen_KF:,Prog. Biochem. Pharmacol.,1985,20,1
LBF20503LT01 Biological Activity=Leukotriene B5 is about 1/30 as active as leukotriene B4 in stimulating aggregation of rat neutrophils, migration and lysosomal enzyme release of human polymorphonuclear leukocytes, and bradykinin-induced vascular permeability [[Reference:Terano_T:Salmon_JA:Moncada_S:,Prostaglandins,1984,27,217
LBF20503SC01 Biological Activity=Considered to be the major reason for the beneficial effects of fish oils on the cardiovascular system. EPA is a precursor to series 3 eicosanoids that promote dilation of blood vessels and a slower blood clotting reaction and, as such, has been found to be critical to the maintenance of normal cardiovascular health. [[Reference:Bang_HO:Dyerberg_J:,Acta Med. Scand.,1972,192,85
LBF22107PG02 Biological Activity=1a,1b-dihomo PGE1 is produced during incubation of whole sheep seminal vessels but not in human. 1a,1b-dihomo PGE1 has been reported the activity in ex vivo preparations of rat aorta and rat PRP.[[Reference:Dennis_EA:,J. Biol. Chem.,1994,269,13057
LBF22209PG13 Biological Activity=20-ethyl PGF2 α is considered as an intraocular hypotensive agent compared to unoprostone, due to the natural15(S) allylic hydroxyl in the lower side chain.
LBF222nnPG01 Biological Activity=16-phenyl tetranor Prostaglandin E2 induces hypotation in dogs and inhibit bronchoconstriction induced by histamine.[[Reference:Johnson_MR:Schaaf_TK:Constantine_JW:Hess_HJ:,Prostaglandins,1980,20,515
LBF22408AM01 Biological Activity=[[:Template:Image200
LBF22408AM02 Biological Activity=[[:Template:Image200
LBF22408AM03 Biological Activity=[[:Template:Image200
LBF22408AM04 Biological Activity=[[:Template:Image200
LBF22408AM05 Biological Activity=[[:Template:Image200
LBF22603SC01 Biological Activity=DHA is one of the n-3 ( ω 3) fatty acids. It is uniquely rich in neural membranes of retina and brain in mammals. n-3 fatty acid deficiency causes the reduction of DHA level in these tissues and produces reduced learning ability [[Reference:Yamamoto_N:Saitoh_M:Moriuchi_A:Nomura_M:Okuyama_H:,J. Lipid. Res.,1987,28,144
LBF232nnPG01 Biological Activity=17-phenyl trinor Prostaglandin E2 shows constriction of the guinea pig ileum and strong anti-fertility effect in hamster.[[Reference:Miller_WL:Weeks_JR:Lauderdale_JW:Kirton_KT:,Prostaglandins,1975,9,9
LBF232nnPG02 Biological Activity=17-phenyl trinor Prostaglandin F2 α reduces the intraocular pressure in the cat eye.[[Reference:Yokotani_K:Nishihara_M:Murakami_Y:Hasegawa_T:Okuma_Y:Osumi_Y:,Br. J. Pharmacol.,1995,115,672
LBF232nnPG03 Biological Activity=17-phenyl trinor PGF2 α amide is expected to show the typical intraocular effects of latanoprost. In vivo study revlealed that 17-phenyl trinor PGF2 α amide was converted the amides of various PGs to the free acids.[[Reference:Woodward_DF:Krauss_AH:Chen_J:Lai_RK:Spada_CS:Burk_RM:Andrews_SW:Shi_L:Liang_Y:Kedzie_KM_et_al:,Surv. Ophthalmol.,2001,45 Suppl 4,S337
LBF232nnPG04 Biological Activity=In the monky, 17-phenyl trinor PGF2 α isopropyl ester shows the most potent activity in reducing IOP, lowering the IOP 1.3 mmHg below the level achieved by latanoprost at the dose of 3 mg/eye.
LBF36000SC01 Biological Activity= [[Reference:Abramovitch_B:Hausser_CR:,J. Am. Chem. Soc.,1942,64,2720
LBF37000SC01 Biological Activity= [[Reference:Abramovitch_B:Hausser_CR:,J. Am. Chem. Soc.,1942,64,2720


Personal tools